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Merck

E4404

Sigma-Aldrich

Anti-EphA8 antibody produced in goat

affinity isolated antibody, lyophilized powder

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About This Item

MDL number:
UNSPSC Code:
51111800
NACRES:
NA.41

biological source

goat

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse

technique(s)

indirect ELISA: 0.5-1.0 μg/mL
western blot: 0.1-0.2 μg/mL

UniProt accession no.

storage temp.

−20°C

Gene Information

mouse ... Epha8(13842)

General description

The antibody demonstrates ~5% cross-reactivity with recombinant mouse EphA6, EphA7, EphA2, and EphA3 in ELISA and immunoblotting assays. Also, there is approximately 5% cross-reactivity with recombinant human EphA1 and recombinant rat EphA5.

Immunogen

purified recombinant mouse EphA8 extracellular domain.

Biochem/physiol Actions

EPH receptor A8 is a protein-tyrosine kinase family that belongs to the ephrin receptor subfamily. It regulates developmental events, particularly those of the nervous system. EphA8 binds p110γ isoform of PI3-kinase and regulates the integrin-mediated cell adhesion.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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C Gu et al.
Molecular and cellular biology, 21(14), 4579-4597 (2001-06-21)
Recent genetic studies suggest that ephrins may function in a kinase-independent Eph receptor pathway. Here we report that expression of EphA8 in either NIH 3T3 or HEK293 cells enhanced cell adhesion to fibronectin via alpha(5)beta(1)- or beta(3) integrins. Interestingly, a
eph, the largest known family of putative growth factor receptors.
N L Tuzi et al.
British journal of cancer, 69(3), 417-421 (1994-03-01)

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