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E3256

Edrophonium chloride

Name: Edrophonium chloride
Brand: SIGMA

Sinónimos:

Ethyl(m-hydroxyphenyl)dimethylammonium chloride

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About This Item

Fórmula empírica (notación de Hill):

C₁₀H₁₆ClNO

Número de CAS:

116-38-1

Peso molecular:

201.69

EC Number:

204-138-4

MDL number:

MFCD00055064

UNSPSC Code:

12352200

PubChem Substance ID:

24278414

SMILES string

[Cl-].CC[N+](C)(C)c1cccc(O)c1

InChI

1S/C10H15NO.ClH/c1-4-11(2,3)9-6-5-7-10(12)8-9;/h5-8H,4H2,1-3H3;1H

InChI key

BXKDSDJJOVIHMX-UHFFFAOYSA-N

Gene Information

human ... ACHE(43)

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Biochem/physiol Actions

Acetycholinesterase inhibitor

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Failure to reverse prolonged vecuronium-induced neuromuscular blockade with edrophonium in an anesthetized dog.

Manuel Martin-Flores et al.

Journal of the American Animal Hospital Association, 47(4), 294-298 (2011-06-16)

A case of prolonged muscle relaxation after vecuronium in an anesthetized dog is presented. After using peripheral nerve stimulation to confirm partial recovery of neuromuscular transmission, administration of 0.5 mg/kg IV of intravenous edrophonium failed to complete the reversal process.

Reversal of asynchrony between circular and longitudinal muscle contraction in nutcracker esophagus by atropine.

Hariprasad Korsapati et al.

Gastroenterology, 135(3), 796-802 (2008-08-05)

Patients with high-amplitude esophageal contractions (nutcracker esophagus [NCE]) show asynchrony of circular muscle (CM) and longitudinal muscle (LM) contraction during peristalsis. The goal of our study was to determine if this asynchrony is related to an increase in the cholinergic

Design, synthesis, and biological evaluation of coumarin derivatives tethered to an edrophonium-like fragment as highly potent and selective dual binding site acetylcholinesterase inhibitors.

Leonardo Pisani et al.

ChemMedChem, 5(9), 1616-1630 (2010-08-03)

A large series of substituted coumarins linked through an appropriate spacer to 3-hydroxy-N,N-dimethylanilino or 3-hydroxy-N,N,N-trialkylbenzaminium moieties were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. The highest AChE inhibitory potency in the 3-hydroxy-N,N-dimethylanilino series was observed with a

Congenital myasthenic syndromes: current diagnostic and therapeutic approaches.

Ulrike Schara et al.

Neuropediatrics, 43(4), 184-193 (2012-08-23)

Congenital myasthenic syndromes (CMS) are rare genetically and clinically heterogeneous disorders characterized by an impaired neuromuscular transmission. Exact prevalence data are not available, approximately 2000 to 3000 patients worldwide have been diagnosed on a molecular level; mutations in 14 different

Case report: A young man with progressive weakness, double vision and breathlessness.

Laura A Benjamin et al.

Malawi medical journal : the journal of Medical Association of Malawi, 23(3), 94-95 (2011-09-01)

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