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E3148

Sigma-Aldrich

Endomorphin 2

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About This Item

Fórmula empírica (notación de Hill):
C32H37N5O5
Número de CAS:
141801-26-5
Peso molecular:
571.67
Número MDL:
MFCD01321064
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329799042

temp. de almacenamiento

−20°C

cadena SMILES

N[C@@H](Cc1ccc(O)cc1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](Cc4ccccc4)C(N)=O

InChI

1S/C32H37N5O5/c33-25(18-23-13-15-24(38)16-14-23)32(42)37-17-7-12-28(37)31(41)36-27(20-22-10-5-2-6-11-22)30(40)35-26(29(34)39)19-21-8-3-1-4-9-21/h1-6,8-11,13-16,25-28,38H,7,12,17-20,33H2,(H2,34,39)(H,35,40)(H,36,41)/t25-,26-,27-,28-/m0/s1

Clave InChI

XIJHWXXXIMEHKW-LJWNLINESA-N

Información sobre el gen

human ... OPRM1(4988)
mouse ... OPRM1(18390)
rat ... OPRM1(25601)

Amino Acid Sequence

Tyr-Pro-Phe-Phe-NH2

Descripción general

Endomorphin 2 is an endogenous ligand for μ-opioid receptor (MOR). It is a neuropeptide and has the sequence Tyr-Pro-Phe-Phe-NH2. It has a greater affinity for MOR1 receptor than MOR2. It resides in primary sensory afferent fibers, and might be the predominant ligand to regulate pain perception. In dynorphin-induced allodynia mice models, endomorphin has anti-allodynic effects. In tail flick test, it produces short-lived antinociception, which is naloxone-sensitive.

Acciones bioquímicas o fisiológicas

Potent, selective endogenous μ opioid receptor agonist.

Información legal

Sold under license to US patent number 6,303,578

Código de clase de almacenamiento

13 - Non Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
044M4750V
071M4806V
049K4807
048K4851
067K4852

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Tingyou Li et al.
Journal of medicinal chemistry, 50(12), 2753-2766 (2007-05-15)
Endomorphin-2 (H-Tyr-Pro-Phe-Phe-NH2) and [Dmt1]EM-2 (Dmt = 2',6'-dimethyl-l-tyrosine) analogues, containing alkylated Phe3 derivatives, 2'-monomethyl (2, 2'), 3',5'- and 2',6'-dimethyl (3, 3', and 4', respectively), 2',4',6'-trimethyl (6, 6'), 2'-ethyl-6'-methyl (7, 7'), and 2'-isopropyl-6'-methyl (8, 8') groups or Dmt (5, 5'), had the
Renata Perlikowska et al.
Bioorganic & medicinal chemistry, 17(11), 3789-3794 (2009-05-14)
Endogenous mu-opioid receptor (MOR) selective peptides, endomorphin-1 (EM-1) and endomorphin-2 (EM-2), unlike so called 'typical opioids', are characterized by the presence of Pro(2) residue, which is a spacer connecting aromatic pharmacophoric residues. In order to investigate structural requirements for position
Gianfranco Balboni et al.
Journal of medicinal chemistry, 49(18), 5610-5617 (2006-09-01)
Substitution of Gly with side-chain-protected or unprotected Lys in lead compounds containing the opioid pharmacophore Dmt-Tic [H-Dmt-Tic-Gly-NH-CH(2)-Ph, mu agonist/delta antagonist; H-Dmt-Tic-Gly-NH-Ph, mu agonist/delta agonist; and H-Dmt-Tic-NH-CH(2)-Bid, delta agonist (Bid = 1H-benzimidazole-2-yl)] yielded a new series of compounds endowed with distinct
I E Goldberg et al.
The Journal of pharmacology and experimental therapeutics, 286(2), 1007-1013 (1998-08-08)
The recently isolated peptides endomorphin-1 and endomorphin-2 have been suggested to be the endogenous ligands for the mu receptor. In traditional opioid receptor binding assays in mouse brain homogenates, both endomorphin-1 and endomorphin-2 competed both mu1 and mu2 receptor sites
Attila Keresztes et al.
Journal of medicinal chemistry, 51(14), 4270-4279 (2008-06-25)
Endomorphins were subjected to a number of structural modifications in a search for their bioactive conformations. The alicyclic beta-amino acids cis-(1 S,2 R)ACPC/ACHC, cis-(1 R,2 S)ACPC/ACHC, trans-(1 S,2 S)ACPC/ACHC, and trans-(1 R,2 R)ACPC/ACHC were introduced into endomorphins to examine the
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