Saltar al contenido
Merck

Documentos clave

Ver Toda la documentación

Saltar a

D8375

2-Desoxi-D-glucosa

≥98% (GC), crystalline

Sinónimos:

2-Desoxiglucosa, 2-Desoxi-D-arabinohexosa

Iniciar sesión para ver los precios por organización y contrato.

Seleccione un Tamaño

Cambiar Vistas
A ustedes/SKUDisponibilidadPrecio
10 mg

Disponible para enviar HOYdesdeToluca

MXP 985.00
1 g

Disponible para enviar HOYdesdeToluca

MXP 2,812.00
5 g

Disponible para enviar HOYdesdeToluca

MXP 9,475.00
25 g
Comprobar disponibilidad del carrito
MXP 39,173.00
100 g
Comprobar disponibilidad del carrito
MXP 87,848.00
MXP 65,886.00

Acerca de este artículo

Fórmula empírica (notación de Hill):
C6H12O5
Número CAS:
154-17-6
Peso molecular:
164.16
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
24894205
EC Number:
205-823-0
Beilstein/REAXYS Number:
1723331
MDL number:
MFCD00151328

MXP 985.00

Disponible para enviar HOYDetalles

​
Solicite una orden a granel
Servicio técnico
¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.
Permítanos ayudarle

biological source

synthetic

Quality Segment

200

assay

≥98% (GC)

form

crystalline

technique(s)

gas chromatography (GC): suitable, inhibition assay: suitable

color

white to off-white

mp

146-147 °C (lit.)

solubility

H2O: 0.250 g/5mL

application(s)

clinical research
life science and biopharma
metabolomics

storage temp.

2-8°C

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)CC=O

InChI

1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1

InChI key

VRYALKFFQXWPIH-PBXRRBTRSA-N

General description

La 2-desoxi-D-glucosa, un análogo no metabolizable de la glucosa, altera la glucólisis afectando a la hexocinasa, la etapa limitante de la velocidad de la glucólisis. Fosforilada a 2-DG-P por la hexocinasa, se acumula en la célula, agotando el ATP celular. Este enfoque, eficaz para matar de hambre a las células cancerosas, también puede inhibir las células víricas que dependen de la glucólisis para su replicación. Esta molécula versátil encuentra aplicación en investigación sobre oncología, virología, metabolómica y bioquímica.

Application

La 2-desoxi-D-glucosa (2-DG) se utiliza en la alimentación glucoprívica para invocar y estudiar los procesos de respuesta contrarreguladora (CRR). La 2-desoxi-D-glucosa se utiliza en el desarrollo de estrategias antineoplásicas que implican radiosensibilización y quimiosensibilización y estrés oxidativo.

Biochem/physiol Actions

La 2-desoxi-D-glucosa (2-desoxiglucosa) es un análogo de la glucosa que inhibe la glucólisis a través de sus acciones sobre la hexoquinasa, la etapa limitante de la velocidad de la glucólisis. Es fosforilada por la hexoquinasa a 2-DG-P, que no puede ser metabolizada después por la fosfoglucoisomerasa. Esto provoca la acumulación de 2-DG-P en la célula y el agotamiento del ATP celular. In vitro, se ha demostrado que la 2-desoxiglucosa induce autofagia, aumenta la producción de ROS y activa la AMPK.

Features and Benefits

  • Compuesto de gran pureza adecuado para una amplia variedad de aplicaciones experimentales

Packaging

Frasco de vidrio sin fondo. El contenido está en el interior del cono fundido insertado.

Other Notes

Ganador del premio CiteAb 2024 como proveedor de éxito en la investigación del Parkinson
Si desea conocer por completo nuestra amplia gama de monosacáridos para su investigación, le recomendamos que visite nuestra página de categoría Carbohidratos .
Si desea más información sobre nuestra gama de productos bioquímicos, cumplimente este formulario.

Comparar elementos similares

Ver comparación completa

Mostrar Diferencias

1 of 1

Este artículo
D6134D3179M0285
2-Desoxi-D-glucosa ≥98% (GC), crystalline

Sigma-Aldrich

D8375

2-Desoxi-D-glucosa

2-Desoxi-D-glucosa ≥99% (GC), crystalline

Sigma-Aldrich

D6134

2-Desoxi-D-glucosa

2-Desoxi-D-glucosa ≥98% (GC), BioXtra

Sigma-Aldrich

D3179

2-Desoxi-D-glucosa

Methyl-β-D-galactopyranoside

Sigma-Aldrich

M0285

Methyl-β-D-galactopyranoside

biological source

synthetic

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

synthetic

assay

≥98% (GC)

assay

≥99% (GC)

assay

≥98% (GC)

assay

≥98% (GC)

technique(s)

gas chromatography (GC): suitable, inhibition assay: suitable

technique(s)

gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable

solubility

H2O: 0.250 g/5mL

solubility

H2O: soluble 330 mg/mL, clear, colorless

solubility

H2O: 1 M at 20 °C, clear, colorless

solubility

water: 50 mg/mL, clear, colorless

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

crystalline

form

crystalline

form

powder

form

powder

Still not finding the right product?

Explore all of our products under 2-Desoxi-D-glucosa

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documentos section.

Si necesita más asistencia, póngase en contacto con Atención al cliente

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Questions

1–4 of 4 Questions  

  1. Does this help fight herpe virus

    1 answer

    1. 2-Deoxy-D-glucose (2-DG) is an compound that has been studied as an antiviral agent against herpes simplex virus (HSV-1 and HSV-2)l, it is suitable for research applications. This product has not been used specifically in HSV-1 or HSV-2 applications.

      Please note that this product is not suitable for human or animal consumption. Unless otherwise stated, this product is intended for research use only. It is not suitable for any other purpose, which includes, but is not limited to, unauthorized commercial use, in vitro diagnostic use, or therapeutic use in humans or animals.

      Helpful?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  4. Can 2DG here (D8375) be dissolved in DMSO? For the same, D6134, product you mention down in the comments' section "The chemical can be solubilized in DMSO (up to 190 mg/ml)". Also, can I dilute the product in situ, directly inside the container?

    1 answer

    1. Both the D8375 and the D6134 should be soluble in DMSO, according to published literature. The D6134 is a purified version of the D8375. The solubility rates may differ. Note that the solubility information cited in the link below has not been verified.
      http://www.plantcell.org/content/14/6/1293.full)

      Helpful?

Reviews

No rating value

Active Filters