D4317
3,5-Diiodothyropropionic acid
Sinónimos:
DITPA
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Fórmula empírica (notación de Hill):
C15H12I2O4
Número CAS:
Peso molecular:
510.06
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Servicio técnico
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Permítanos ayudarlestorage temp.
2-8°C
SMILES string
OC(=O)CCc1cc(I)c(Oc2ccc(O)cc2)c(I)c1
Biochem/physiol Actions
DITPA, an analog of L-thyroxine, has inotropic but not chronotropic effects on heart muscle. It also stimulates myocardial angiogenesis after infarction by interaction with integrin αvཪ3 at the cell surface.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Clase de almacenamiento
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Najah R Hadi et al.
BMC nephrology, 12, 70-70 (2011-12-27)
Acute renal failure (ARF) is an important clinical problem with a high mortality and morbidity. One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886
M A Hassan Talukder et al.
American journal of physiology. Heart and circulatory physiology, 300(2), H702-H711 (2010-12-07)
There is emerging evidence that treatment with thyroid hormone (TH) can improve postischemic cardiac function. 3,5-Diiodothyropropionic acid (DITPA), a TH analog, has been proposed to be a safer therapeutic agent than TH because of its negligible effects on cardiac metabolism
Reza Arsanjani et al.
Journal of molecular and cellular cardiology, 51(4), 506-511 (2011-01-11)
Thyroid hormone has unique properties affecting the heart, and the vasculature and cholesterol metabolism. There is interest in using thyromimetic agents as possible treatment options for heart failure based on data demonstrating the ability of these agents to improve systolic