C7971

Cilostamide

phosphodiesterase inhibitor

• Sinónimos: 6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one, OPC 3689
• Fórmula empírica (notación de Hill): C₂₀H₂₆N₂O₃
• Número de CAS: 68550-75-4
• Peso molecular: 342.43
• Número MDL: MFCD00673958
• Código UNSPSC: 12352202
• ID de la sustancia en PubChem: 24278337
• NACRES: NA.77

Propiedades

• Ensayo: ≥97% (HPLC)
• Formulario: powder
• solubilidad: DMSO: 20 mg/mL, clear, colorless to faintly yellow
• cadena SMILES: CN(C1CCCCC1)C(=O)CCCOc2ccc3NC(=O)C=Cc3c2
• InChI: 1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
• Clave InChI: UIAYVIIHMORPSJ-UHFFFAOYSA-N
• Información sobre el gen: human ... PDE3A(5139) , PDE3B(5140) , PDE5A(8654) , PDE7A(5150) ; rat ... Pde2a(81743) , Pde4a(25638)

Descripción

Acciones bioquímicas o fisiológicas

PDE3 catalyzes the phosphodiester bond hydrolysis, observed in secondory messengers such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Inhibitors of PDE3 are generally inotropic and vasodilatory. They are being recognized for its use in treating heart failures.[1] Cilostamide is known to delay meiotic progression.[2]

Selective cGMP-inhibited phosphodiesterase inhibitor (PDE3); IC₅₀ = 70 ± 9 nM.

Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC₅₀ = 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)