Saltar al contenido
Merck
Todas las fotos(1)

Documentos clave

Ver Toda la documentación

C7870

Sigma-Aldrich

Chalcone 4 hydrate

≥98% (HPLC)

Sinónimos:

(E)-1-(4-Chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one hydrate

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C16H13ClO3 · xH2O
Número de CAS:
1202866-96-3
Peso molecular:
288.73 (anhydrous basis)
MDL number:
MFCD12912407
UNSPSC Code:
51111800
PubChem Substance ID:
329775154
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

yellow

solubility

DMSO: >20 mg/mL

storage temp.

−20°C

SMILES string

O.COc1cc(ccc1O)\C=C\C(=O)c2ccc(Cl)cc2

InChI

1S/C16H13ClO3.H2O/c1-20-16-10-11(3-9-15(16)19)2-8-14(18)12-4-6-13(17)7-5-12;/h2-10,19H,1H3;1H2/b8-2+;

InChI key

PXVQKTVKTBMRIW-VOKCZWNHSA-N

Biochem/physiol Actions

Chalcone 4 is a potent, selective inhibitor of the chemokine CXCL12 via direct binding. It is also a small molecule anti-ligand (or neutraligand) of CXCR4 and CXCR7. The chemokine CXCL12 (stromal cell-derived factor-1) and its receptors play pivotal roles in inflammatory responses, normal vascular and neuronal development, as well as in infectious diseases and cancer. Chalcone 4 binds to and activates the chemokine receptors CXCR4 and CXCR7 and stimulates a rapid receptor-mediated intracellular calcium mobilization and signaling through a Pertussis toxin sensitive Gi protein. Chalcone 4 potently and selectively inhibits CXCL12 binding to CXCR4 and CXCR7, and consequent CXCL12-evoked calcium cellular responses. Chalcone 4 binds to the chemokine CXCL12, but not to its receptors.

Features and Benefits

This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Environment
GHS09

signalword

Warning

hcodes

H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Alexander Kaltenborn et al.
PloS one, 9(3), e91560-e91560 (2014-03-14)
This study introduces and validates the Hip Lag Sign, a new clinical parameter to determine hip abductor damage, which appears to be one major cause for greater trochanteric pain syndrome. 26 patients who underwent standardized MRI-examination were prospectively enrolledbetween October
HyeKyung Han et al.
Clinical drug investigation, 34(6), 373-382 (2014-03-14)
GC1113, a hybrid Fc-fused erythropoietin, is a novel erythropoiesis-stimulating agent that is expected to have an extended duration of action. The preclinical data showed that the hemoglobin increase lasted longer following GC1113 administration than it did following the administration of
Masahiro Yamazaki et al.
PloS one, 9(3), e91860-e91860 (2014-03-14)
Visualization of white matter (WM)-tracts such as the corticospinal tract (CST), medial lemniscus (ML), and superior cerebellar peduncle (SCP) using delayed enhanced (DE)-heavily T2-weighted three-dimensional fluid-attenuated inversion-recovery (hT2w-3D-FLAIR) imaging has recently been reported. In that report, all patients were clinically
Aaron Krych et al.
The journal of knee surgery, 28(1), 83-88 (2014-03-14)
The purpose of this study was to determine if quadriceps strength and functional outcomes were similar at 6 months following anterior cruciate ligament [ACL] reconstruction in patients receiving a continuous 48-hour femoral nerve blockade for postoperative analgesia (FNB group) versus
Anna Y Kharmats et al.
The American journal of clinical nutrition, 99(5), 1006-1014 (2014-03-14)
There has been limited research regarding the Supplemental Nutritional Assistance Program (SNAP) and recipients' dietary quality during the days and weeks after benefit disbursement. We examined the relation between participants' stages in the SNAP cycle and their macronutrient consumption, Healthy
Ver todos los artículos relacionados

Artículos

Chemokine Receptors

We offer many products related to chemokine receptors for your research needs.

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico