C7863

Anti-Csk antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• MDL number: MFCD01633277
• UNSPSC Code: 12352203

Propiedades

• biological source: rabbit
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 50 kDa
• species reactivity: human, rat
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200 using rat spleen; microarray: suitable; western blot: 1:2,000 using a whole cell extract of human Jurkat cell line and a cytosolic fraction of embryonic rat brain
• UniProt accession no.: P41240
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... CSK(1445) ; mouse ... Csk(12988) ; rat ... Csk(315707)

Descripción

General description

Csk is a widely expressed non-receptor tyrosine kinase that consists of a catalytic domain, as well as SH2 and SH3 domains. This kinase phosphorylates the C-terminal tail of Src-family protein tyrosine kinases (SFKs) and subsequently inhibits SFKs. As SFKs have been associated carcinogenesis, Csk may have implications in cancer therapeutics
Anti-Csk antibody is specific for human and rat Csk. The product may also react with mouse Csk. In immunoblotting, staining of Csk is specifically inhibited with the Csk immunizing peptide (rat, amino acids 433-450).

Immunogen

peptide corresponding to amino acids 433-450 at the C-terminus of rat Csk. This sequence is highly conserved in human and mouse.

Application

Anti-Csk antibody is suitable for use in western blot (1:2,000 using whole cell extracts of human Jurkat cell line and cytosolic fractions of embryonic rat brain). The product may also be used for microarray and immunohistochemistry (1:200 using formalin-fixed, paraffin-embedded sections of rat spleen).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.