C7740
Anti-phospho-α-B Crystallin (14-25) (pSer19) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
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About This Item
origen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
lyophilized powder
reactividad de especies
rat, bovine, human, mouse
técnicas
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 10 μg/mL
indirect immunofluorescence: 5 μg/mL
western blot: 0.5 μg/mL using human cell extract
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
phosphorylation (pSer19)
Información sobre el gen
human ... CRYAB(1410)
mouse ... Cryab(12955)
rat ... Cryab(25420)
Especificidad
Does not detect the unphosphorylated protein.
Inmunógeno
synthetic phosphopeptide surrounding the region of human α-B crystallin that contains serine 19.
Aplicación
Anti-phospho-α-B Crystallin (14-25) (pSer19) antibody produced in rabbit
- Immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 10μg/mL
- Indirect immunofluorescence at a concentration of 5μg/mL
- Western blotting at a concentration of 0.5μg/mL using human cell extract
- It also used in 1- and 2-D immune blotting analysis.
Acciones bioquímicas o fisiológicas
α-Crystallin B chain is a protein encoded by the CRYAB gene in humans. αB-crystallin (ABC) and HSP27 are most abundant in human tissues. It is predominantly expressed in triple-negative breast cancer (TNBC) and leads to aggressive tumor phenotype. αB-crystallin expression is primary found in breast carcinomas and brain metastases. αB-crystallin is overexpressed or silenced in two different TNBC cell lines. It is a novel regulator of brain metastasis in TNBC and acts as a potential biomarker for drug target in aggressive disease. αB-crystallin and VEGF expressions in human conjunctival squamous cell carcinoma (CSCCs) may play an important role in the pathogenesis. Mutation in the gene is responsible for a number of inherited human disorders, which include cardiomyopathy, skeletal muscle myopathy and cataracts.
Forma física
Lyophilized from phosphate buffered saline, pH 7.4, containing 3% bovine serum albumin and 0.05% sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Descripción
Precios
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Shuji Ueda et al.
International journal of molecular sciences, 23(19) (2022-10-15)
Protein homeostasis, including protein folding, refolding, and degradation, is thought to decline with aging. HSPB5 (also known as αB-crystallin) prevents target protein aggregation as a molecular chaperone and exhibits a cytoprotective function against various cell stresses. To elucidate the effect
Bimal Prasanna Mohanty et al.
Indian journal of biochemistry & biophysics, 48(1), 35-41 (2011-04-08)
Crystallins are a diverse group of proteins that constitute nearly 90% of the total soluble proteins of the vertebrate eye lens and these tightly packed crystallins are responsible for transparency of the lens. These proteins have been studied in different
Zhenyu Dong et al.
Anticancer research, 33(9), 3745-3751 (2013-09-12)
To examine the expression of αB-crystallin and vascular endothelial growth factor (VEGF) in conjunctival squamous cell carcinoma (CSCC). Seven CSCCs and three normal conjunctivas that were surgically excised were studied. Paraformaldehyde-fixed, paraffin-embedded tissue sections were processed for immunohistochemistry with antibodies
Dmitry Malin et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(1), 56-67 (2013-10-18)
Basal-like breast tumors are typically (ER/PR/HER2) triple-negative and are associated with a high incidence of brain metastases and poor clinical outcomes. The molecular chaperone αB-crystallin is predominantly expressed in triple-negative breast cancer (TNBC) and contributes to an aggressive tumor phenotype
Heng B Xie et al.
PLoS genetics, 9(6), e1003544-e1003544 (2013-07-03)
Dominant mutations in the alpha-B crystallin (CryAB) gene are responsible for a number of inherited human disorders, including cardiomyopathy, skeletal muscle myopathy, and cataracts. The cellular mechanisms of disease pathology for these disorders are not well understood. Among recent advances
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