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Merck

C7527

Sigma-Aldrich

Cloruro de colina

BioReagent, suitable for cell culture, suitable for insect cell culture, ≥98%

Sinónimos:

Cloruro de (2-hidroxietil)trimetilamonio

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100 G
MXP 1,236.00
500 G
MXP 3,019.00
1 KG
MXP 4,961.00

MXP 1,236.00


Fecha estimada de envío31 de mayo de 2025


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100 G
MXP 1,236.00
500 G
MXP 3,019.00
1 KG
MXP 4,961.00

About This Item

Fórmula lineal:
(CH3)3N(Cl)CH2CH2OH
Número de CAS:
Peso molecular:
139.62
Beilstein:
3563126
Número CE:
Número MDL:
Código UNSPSC:
12352205
ID de la sustancia en PubChem:
NACRES:
NA.75

MXP 1,236.00


Fecha estimada de envío31 de mayo de 2025


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origen biológico

synthetic (organic)

Línea del producto

BioReagent

Ensayo

≥98%

Formulario

crystals

mol peso

Mw 139.62 g/mol

técnicas

cell culture | insect: suitable
cell culture | mammalian: suitable
cell culture | plant: suitable

color

white

pH

5.0-6.5 (25 °C, 140 g/L)

mp

302-305 °C (dec.) (lit.)

solubilidad

H2O: 50 mg/mL

cadena SMILES

[Cl-].C[N+](C)(C)CCO

InChI

1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1

Clave InChI

SGMZJAMFUVOLNK-UHFFFAOYSA-M

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Descripción general

Choline chloride is a quaternary ammonium salt and associates with hydrogen bond donors (HBD).[1] It is essential for the vital physiological functions and is used as a nutritional additive. Choline is a source of methyl groups for methyl-transfer reactions.[2]

Aplicación

Choline chloride has been used:
  • as a component of choline acetyltransferase (ChAT) buffer and for choline uptake in cultured human neuroblastoma (SK-N-SH) cells[3]
  • for choline standard curve generation for quantifying phospholipase D (PLD) activity[4]
  • as a component of slice solution for the dissection of entorhinal-hippocampal brain slices[5]

Sustratos

Sustrato de la colina acetiltransferasa

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves


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Certificados de análisis (COA)

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Visite la Librería de documentos

Harvie P Portugaliza et al.
Scientific reports, 9(1), 14595-14595 (2019-10-12)
Transmission of malaria parasites from humans to mosquito vectors requires that some asexual parasites differentiate into sexual forms termed gametocytes. The balance between proliferation in the same host and conversion into transmission forms can be altered by the conditions of
Choline: an essential nutrient for public health
Zeisel SH and Da Costa KA
Nutr. Rev, 67(11), 615-623 (2009)
Synthesis and characterization of choline chloride based binary mixtures
Abbas Q and Binder L
ECS Transactions, 33(7), 49-59 (2010)
Apoptosis of bovine granulosa cells: Intracellular pathways and differentiation
Carou MC, et al.
Acta Histochemica, 119(5), 462-470 (2017)
Zhenglin Gu et al.
Cell reports, 31(10), 107740-107740 (2020-06-11)
Muscarinic acetylcholine receptors (mAChRs) are critically involved in hippocampal theta generation, but much less is known about the role of nicotinic AChRs (nAChRs). Here we provide evidence that α7 nAChRs expressed on interneurons, particularly those in oriens lacunosum moleculare (OLM)

Questions

1–3 of 3 Questions  
  1. Choline chloride will be melted in water for addition to the medium. Can you please tell me the proper storage method, such as -30°C freezing ay -4°C refrigeration?

    1 answer
    1. This product is soluble in water at 50 mg/mL. The storage and stability conditions for this product upon reconstitution have not been determined.

      Helpful?

  2. Hi, is it possible to thaw choline chloride in PBS instead of water and add it to the medium?

    1 answer
    1. This product is soluble in water, tested at 50 mg/mL. Solubility in PBS has not been determined in-house. Literature suggests that choline chloride can be prepared with PBS. For reference, see https://en-cdn.bio-protocol.org/pdf/Bio-protocol807.pdf?rel_link=YmlvLXByb3RvY29sLm9yZy9lbi9icGRldGFpbD9pZD04MDcmdHlwZT0w

      Helpful?

  3. Hi, could you please provide the product information sheet for Choline chloride.

    1 answer
    1. There is no specific product information sheet offered for Choline Chloride. Please see the PROPERTIES section of the product page for details. Links to a sample Certificate of Analysis and a Certificate of Origin are provided below:

      Certificate of Analysis
      https://www.sigmaaldrich.com/certificates/COFA/C7/C7527/C7527-100G________SLBB8921V_.pdf

      Certificate of Origin
      https://www.sigmaaldrich.com/US/en/coo/undefined/C7527/SLBB8921V

      Helpful?

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