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Documentos

C6734

Sigma-Aldrich

CAY10397

solid, >98%

Sinónimos:

5-[[4-(Ethoxycarbonyl)phenyl]azo]-2-hydroxybenzeneacetic acid, CK47A

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About This Item

Fórmula empírica (notación de Hill):
C17H16N2O5
Número de CAS:
78028-01-0
Peso molecular:
328.32
MDL number:
MFCD03412024
UNSPSC Code:
12352200
PubChem Substance ID:
329775130
NACRES:
NA.77

product name

CAY10397, >98%, solid

Quality Level

200

assay

>98%

form

solid

shipped in

wet ice

storage temp.

−20°C

SMILES string

CCOC(=O)c1ccc(cc1)\N=N\c2ccc(O)c(CC(O)=O)c2

InChI

1S/C17H16N2O5/c1-2-24-17(23)11-3-5-13(6-4-11)18-19-14-7-8-15(20)12(9-14)10-16(21)22/h3-9,20H,2,10H2,1H3,(H,21,22)/b19-18+

InChI key

YYBSDOZYJSGLTH-VHEBQXMUSA-N

Biochem/physiol Actions

Potent and selective inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-hydroxy-PGDH). Acts to prolong the lifetime and activity of endogenously produced prostaglandins both in vitro and in vivo.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Christian Hunnicke Petersen et al.
BMC cancer, 19(1), 643-643 (2019-06-30)
Investigations of colorectal carcinogenesis have mainly focused on examining neoplastic tissue. With our aim of identifying potentially cancer-predisposing molecular compositions, we chose a different approach by examining endoscopically normal appearing colonic mucosa of patients with and without colorectal neoplasia (CRN).
Shaneice K Nettleford et al.
Frontiers in nutrition, 7, 96-96 (2020-08-11)
Enteropathogenic Escherichia coli (EPEC) leads to adverse colonic inflammation associated with poor resolution of inflammation and loss of epithelial integrity. Micronutrient trace element selenium (Se) is incorporated into selenoproteins as the 21st amino acid, selenocysteine (Sec). Previous studies have shown
Liuping Wei et al.
Cellular signalling, 26(7), 1476-1488 (2014-03-25)
We have established that 15-hydroxyeicosatetraenoic acid is an important factor in regulation of pulmonary vascular remodeling (PVR) associated with hypoxia-induced pulmonary hypertension (PH), which is further metabolized by 15-hydroxyprostaglandin dehydrogenase (15-PGDH) to form 15-ketoeicosatetraenoic acid (15-KETE). However, the role of

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