C5738

Anti-Calcium Channel (β₂ subunit) (Voltage Gated Ca²⁺ Channel) antibody produced in rabbit

~1 mg/mL, fractionated antiserum, buffered aqueous solution

• MDL number: MFCD04974684
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• Quality Level: 200
• conjugate: unconjugated
• antibody form: fractionated antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: rat, human, mouse
• concentration: ~1 mg/mL
• technique(s): western blot: 5-10 μg/mL using brain tissues lysate
• UniProt accession no.: Q08289
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CACNB2(783) ; mouse ... Cacnb2(12296) ; rat ... Cacnb2(116600)

Descripción

General description

CACNB2 (Voltage-dependent L-type calcium channel subunit β-2) is particularly expressed in cardiovascular tissue.

Specificity

Specifically recognizes a splice variant of β₂ (68 kDa) from human, mouse and rat.

Immunogen

synthetic peptide derived from the rat β₂ calcium channel subunit conjugated to KLH.

Application

Anti-Calcium Channel (β2 subunit) antibody produced in rabbit is suitable for western blot at a concentration of 5-10μg/mL using rat brain tissue lysate.

Biochem/physiol Actions

CACNB2 (Voltage-dependent L-type calcium channel subunit β-2) is a subunit of voltage-activated L-type calcium channelsl. CACNB2 regulates voltage-dependent calcium currents through direct interaction with α1 subunits. Loss of function mutation in CACNB2 is associated with familial cardiac death combined with short QT intervals and ST-segment elevation. It is down-regulated in humans with atrial fibrillation and miR-21 is suggested to be responsible for the down-regulation. Mutations in CACNB2 are linked to autism spectrum disorders.

Physical form

Solution in phosphate buffered saline containing 0.08% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.