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Merck
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C5135

Sigma-Aldrich

Castor Oil, Ethoxylated

pH range 6.0-8.0

Sinónimos:

Cremophor® EL, EL, Macrogolglycerol ricinoleate, PEG-35 castor oil, Polyoxyl-35 castor oil

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500 G
MXP 3,116.00
1 KG
MXP 5,754.00

MXP 3,116.00

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500 G
MXP 3,116.00
1 KG
MXP 5,754.00

About This Item

Número de CAS:
61791-12-6
MDL number:
MFCD00130879
UNSPSC Code:
12161902
NACRES:
NA.25

MXP 3,116.00

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description

non-ionic

Quality Level

200

form

liquid

mol wt

~2500 g/mol

pH range

6.0-8.0

HLB

12 - 14

application(s)

sample preservation

SMILES string

ClCC(OC(=O)N)CCl

InChI

1S/C4H7Cl2NO2/c5-1-3(2-6)9-4(7)8/h3H,1-2H2,(H2,7,8)

InChI key

JMNCUXPHXKHBPY-UHFFFAOYSA-N

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General description

Castor Oil, Ethoxylated is a nonionic solubilizer and emulsifier made by reacting castor oil with ethylene oxide. It is a pale yellow oily liquid that is clear at temperatures above 26°C. It has a faint but characteristic odour.
Castor Oil, Ethoxylated is polyethylene oxide surfactant and is viscous in nature. It has a hydrophobic-lipophilic balance value in the range of 12-14.[1]

Application

Castor Oil, Ethoxylated has been used as a detergent to improve the solubility of dye and to increase the transmembrane permeation.[2][3] It has been used as a vehicle for drug/stimulant delivery in cells.[4][5]

Biochem/physiol Actions

Castor Oil, Ethoxylated is used in lipid-based formulations for drugs and solubilization of cosmetics.[1] Castor Oil, Ethoxylated is suitable for the production of semi-solid and liquid formulations of water-insoluble actives and other hydrophobic compounds.[1] Due to its emulsification functionality, it finds application in biological membrane- based drug transport studies.[6]

Other Notes

A derivative of castor oil and ethylene oxide.

Legal Information

Cremophor is a registered trademark of BASF SE

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

494.6 °F - Not applicable

flash_point_c

257 °C - Not applicable

ppe

Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
BCCL7415
BCCL7416
BCCM3065
BCCK9841
BCCJ9623

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Large-scale imaging of cortical network activity with calcium indicators.
Ikegaya Y
Neuroscience Research, 52, 132-132 (2005)
Triiodothyronine reverses depressed contractile performance after excessive catecholamine stimulation.
Timek T
The Annals of Thoracic Surgery, 66, 1618-1618 (1998)
A nonionic polyethylene oxide (PEO) surfactant model: experimental and molecular dynamics studies of Kolliphor EL
Suys EJA, et al.
Journal of Pharmaceutical Sciences, 108(1), 193-204 (2019)
Ida G Lunde et al.
Journal of applied physiology (Bethesda, Md. : 1985), 111(5), 1278-1289 (2011-04-09)
Norepinephrine (NE) and angiotensin II (ANG II) are primary effectors of the sympathetic adrenergic and the renin-angiotensin-aldosterone systems, mediating hypertrophic, apoptotic, and fibrotic events in the myocardium. As NE and ANG II have been shown to affect intracellular calcium in
Yiqiao Wang et al.
Nature communications, 10(1), 4137-4137 (2019-09-14)
Developmental cell death plays an important role in the construction of functional neural circuits. In vertebrates, the canonical view proposes a selection of the surviving neurons through stochastic competition for target-derived neurotrophic signals, implying an equal potential for neurons to
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Questions

1–9 of 9 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. Can this be stored in -20C?

    1 answer

    1. This product is to be stored at room temperature. Storing the product at freezer temperatures has not been evaluated and may cause degradation.

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  4. How much is the Cloud Point?

    1 answer

    1. The cloud point is not determined.

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  5. What is the hydrophile-lipophile balance (HLB) for Cremophor EL (Product No. C5135)?

    1 answer

    1. The manufacturer (BASF) reports an HLB value of between 12 and 14 for Cremophor EL (Product No. C5135).

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  6. What is the molecular weight of Cremophor EL (Product No. C5135)?

    1 answer

    1. The manufacturer (BASF) reports a molecular weight of approximately 2500 for Cremophor EL (Product No. C5135).

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  7. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  8. How can Cremophor EL (Product No. C5135) be sterilized?

    1 answer

    1. The manufacturer (BASF) recommends that it be sterilized by heating in an autoclave for 30 minutes at 120°C. It may acquire a somewhat deeper color. Either the neat material or neutral aqueous solutions may be autoclaved.

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  9. What solvents can I use to prepare a solution of Cremophor EL (Product No. C5135)? Or is it already in solution?

    1 answer

    1. Cremophor EL is a neat liquid, sold by weight. It is not already in solution. It is soluble in water; note that the solubility in water actually decreases with an increase in temperature. It is also soluble in many organic solvents, such as ethanol, isopropyl alcohol, chloroform and others.

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