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B7775

Sigma-Aldrich

[Hyp3]-Bradykinin

≥97% (HPLC), suitable for cell culture

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About This Item

Fórmula empírica (notación de Hill):
C50H73N15O12
Número de CAS:
37642-65-2
Peso molecular:
1076.21
MDL number:
MFCD00076259
UNSPSC Code:
12352200
PubChem Substance ID:
329773302

Nombre del producto

[Hyp3]-Bradykinin, ≥97% (HPLC)

assay

≥97% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

color

white

UniProt accession no.

P06767

storage temp.

−20°C

SMILES string

N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CO)C(=O)N4CCC[C@H]4C(=O)N[C@@H](Cc5ccccc5)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C50H73N15O12/c51-32(15-7-19-56-49(52)53)45(73)64-22-10-18-38(64)47(75)65-27-31(67)25-39(65)43(71)58-26-40(68)59-34(23-29-11-3-1-4-12-29)41(69)62-36(28-66)46(74)63-21-9-17-37(63)44(72)61-35(24-30-13-5-2-6-14-30)42(70)60-33(48(76)77)16-8-20-57-50(54)55/h1-6,11-14,31-39,66-67H,7-10,15-28,51H2,(H,58,71)(H,59,68)(H,60,70)(H,61,72)(H,62,69)(H,76,77)(H4,52,53,56)(H4,54,55,57)/t31-,32+,33+,34+,35+,36+,37+,38+,39+/m1/s1

InChI key

JXRLHZCEMXTCBN-DIBGMJQNSA-N

Gene Information

rat ... Tac1(24806)

Amino Acid Sequence

Arg-Pro-Hyp-Gly-Phe-Ser-Pro-Phe-Arg

Biochem/physiol Actions

[Hyp3]-Bradykinin is a bradykinin receptor agonist used to differentiate bradykinin receptors in various cells, tissues and species.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
051M1680V
051M1680
060M1517
099K1571
069K1200

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[Structures and functions of kininogen and kinin hydroxyproline derivatives as multi-functional proteins].
H Kato
[Rinsho ketsueki] The Japanese journal of clinical hematology, 30(10), 1690-1693 (1989-10-01)
R Dengler et al.
FEBS letters, 262(1), 111-114 (1990-03-12)
The recently isolated, naturally occurring peptide hormones [Hyp3]-bradykinin and [Hyp3]-Lys-bradykinin were investigated for their agonist activity on solubilized binding sites from human fibroblasts. Both ligands competed with [3H]bradykinin binding in a dose-dependent fashion with potencies similar to bradykinin (BK) and
Y Matsumura et al.
Agents and actions, 29(3-4), 172-180 (1990-03-01)
We have recently found presence of a high concentration of a novel type of kinin, hydroxyprolyl3-bradykinin (Hyp3-BK) in human tumor ascites in addition to conventional bradykinin (BK). Because of their potential physiological activity, it is of interest to know how
D Regoli et al.
Life sciences, 55(10), 735-749 (1994-01-01)
Bradykinin, desArg9BK, some agonist analogues and several antagonists have been tested in isolated organs in order to identify bradykinin B2 receptor subtypes. The initial pharmacological characterization was made in the rabbit jugular vein and the guinea pig ileum, two widely
M Hecker et al.
British journal of pharmacology, 111(1), 238-244 (1994-01-01)
1. To examine the possibility that angiotensin-converting enzyme (ACE) inhibitors modulate the action of bradykinin at the receptor level, their effect on the dilator response to bradykinin was studied in the isolated saline-perfused heart of the rabbit. 2. Continuous infusion
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