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Merck
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B5311

Sigma-Aldrich

Biperiden hydrochloride

≥98% (HPLC), powder

Sinónimos:

1-(5-Bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidinyl)propan-1-ol hydrochloride, Akineton, Akinophyl

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About This Item

Fórmula empírica (notación de Hill):
C21H30ClNO
Número de CAS:
1235-82-1
Peso molecular:
347.92
EC Number:
214-976-2
UNSPSC Code:
12352200
PubChem Substance ID:
329773254

assay

≥98% (HPLC)

form

powder

color

off-white

solubility

DMSO: >20 mg/mL
H2O: insoluble

originator

Abbott

SMILES string

Cl[H].OC(CCN1CCCCC1)(C2CC3CC2C=C3)c4ccccc4

InChI

1S/C21H29NO.ClH/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17;/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2;1H

InChI key

RDNLAULGBSQZMP-UHFFFAOYSA-N

Gene Information

human ... CHRM1(1128)

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Biochem/physiol Actions

Biperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. It is used for the adjunctive treatment of all forms of Parkinson′s Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy. LD50 in rats 750 mg/kg; in dogs 340 mg/kg.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Anna C Ramos et al.
Behavioural brain research, 231(1), 213-216 (2012-04-04)
Cocaine addiction is a public health issue in many countries, stressing the need for more effective treatments. As all drugs of abuse, cocaine acts on the brain reward system, increasing dopamine (DA) levels. Other neurotransmitters such as acetylcholine (ACh) are
W Sperling et al.
Medical hypotheses, 76(5), 720-722 (2011-03-04)
In a regions of interest analysis (ROI) of the most frequent psychiatric disorders (schizophrenia, depression, anxiety, addiction), we found the nucleus lentiformis to be the topographical brain region most frequently cited in connection with these disorders in a regions of
Oruc Allahverdiyev et al.
Behavioural brain research, 225(2), 642-645 (2011-08-23)
Biperiden is one of the most commonly abused anticholinergic drugs. This study assessed its motivational effects in the acquisition of conditioned place preference in rats. Biperiden neither produced place conditioning itself nor enhanced the rewarding effect of morphine. Furthermore, biperiden
A case of schizophrenia with meige syndrome induced by perospirone successfully treated with biperiden.
Sakae Takahashi et al.
The Journal of neuropsychiatry and clinical neurosciences, 25(1), E28-E28 (2013-03-15)
Laila Asth et al.
Brain research bulletin, 87(6), 526-533 (2012-03-08)
The elevated T-maze (ETM) is an apparatus derived from the elevated plus-maze test, which is used to evaluate anxiety. Because anxiety is a biasing factor in models of memory, this study proposed the ETM as a task for the simultaneous
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Artículos

Muscarinic Acetylcholine Receptors

Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.

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