This product has a potency specification of 1.5-2.0 units per mg. The exact value will be listed on the lot specific Certificate of Analysis. See the link below to review a sample Certificate of Analysis: https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/B2434-BULKSLCM6973.pdf
B2434
Sulfato de bleomicina from Streptomyces verticillus
BioXtra, crystalline
Bleomycin sulfate from Streptomyces verticillus
1 of 1 reviewers received a sample product or took part in a promotion
Sinónimos:
Blenoxano, Bleo, Blexano
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| A ustedes/SKU | Disponibilidad | Precio |
|---|---|---|
20 mg | Comprobar disponibilidad del carrito | MXP 34,272.00 |
Acerca de este artículo
Número CAS:
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51111733
EC Number:
232-925-2
MDL number:
Servicio técnico
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Permítanos ayudarleproduct line
BioXtra
Quality Segment
form
crystalline
potency
1.5-2.0 units per mg
technique(s)
cell culture | mammalian: suitable
solubility
H2O: 20 mg/mL, clear, colorless
cation traces
Cu: ≤0.10%
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, neoplastics
mode of action
DNA synthesis | interferes
storage temp.
2-8°C
SMILES string
[O-]S([O-])(=O)=O.C[C@@H](O)[C@@H](NC(=O)[C@@H](C)[C@H](O)[C@@H](C)NC(=O)[C@H](NC(=O)c1nc(nc(N)c1C)[C@H](CC(N)=O)NC[C@H](N)C(N)=O)[C@@H](O[C@@H]2O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]2O[C@@H]3O[C@H](CO)[C@@H](O)[C@@H](OC(N)=O)[C@@H]3O)c4c[nH]cn4)C(=O)NCCc5nc(cs5)-c6ncc(s6)C(=O)NCCC[S+](C)C.C[C@@H](O)[C@@H](NC(=O)[C@@H](C)[C@H](O)[C@@H](C)NC(=O)[C@H](NC(=O)c7nc(nc(N)c7C)[C@H](CC(N)=O)NC[C@H](N)C(N)=O)[C@@H](O[C@@H]8O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]8O[C@@H]9O[C@H](CO)[C@@H](O)[C@@H](OC(N)=O)[C@@H]9O)c%10c[nH]cn%10)C(=O)NCCc%11nc(cs%11)-c%12ncc(s%12)C(=O)NCCC[S+](C)C
InChI
1S/2C55H83N17O21S3.H2O4S/c2*1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-66-26)91-54-43(39(80)37(78)28(16-73)90-54)92-53-40(81)42(93-55(60)88)38(79)29(17-74)89-53)51(87)67-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-68-27(18-94-32)52-65-15-30(95-52)48(84)62-9-7-11-96(5)6;1-5(2,3)4/h2*14-15,18-19,21-25,28-29,34-43,53-54,64,73-75,77-81H,7-13,16-17,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,66,67,69,70,71,72,76,82,83,84,85,86,87,88);(H2,1,2,3,4)/t2*21-,22+,23+,24-,25-,28-,29+,34+,35+,36-,37+,38+,39-,40-,41-,42+,43-,53-,54-;/m00./s1
InChI key
OOXTWFJZZAJGKA-CNLAFNBISA-N
General description
Chemical structure: glycopeptide
Application
Bleomycin Sulfate is an antineoplastic antibiotic isolated from Streptomyces verticillus. It is recommended for use as a cell culture agent at 10-100 μg/mL.
Biochem/physiol Actions
El sulfato de bleomicina se une al ADN, provoca la escisión del ADN monocatenario en secuencias de bases específicas e inhibe la síntesis de ADN. Esta acción inhibidora requiere que la bleomicina se una al oxígeno y a un ion metálico. También puede escindir el ARN en menor grado pero con más selectividad. Actúa como inductor y regulador de la apoptosis e inhibe la angiogénesis tumoral.
Preparation Note
El producto es soluble en agua a 20 mg/ml y es activo durante varios días. Una disolución de 2 unidades/ml en fosfato de potasio neutro 0,1 M debe utilizarse en 14 días. Una disolución es activa durante tres meses a 3 unidades/ml en disolución salina normal.
Other Notes
Este producto es una mezcla de antibióticos glucopeptídicos que contienen bleomicina A2 (70 %) y B2(30 %). Las bleomicinas difieren entre sí en la amina terminal y muestran actividad biológica variable.
Keep container tightly closed in a dry and well-ventilated place, strongly hygroscopic
Disclaimer
Este producto debe conservarse a 2-8°C.
1 of 1
Este artículo | |||
|---|---|---|---|
| antibiotic activity spectrum Gram-negative bacteria, neoplastics, Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria, neoplastics | antibiotic activity spectrum fungi | antibiotic activity spectrum fungi |
| technique(s) cell culture | mammalian: suitable | technique(s) - | technique(s) - | technique(s) cell culture | mammalian: suitable |
| mode of action DNA synthesis | interferes | mode of action DNA synthesis | interferes | mode of action DNA synthesis | interferes | mode of action DNA synthesis | interferes |
| product line BioXtra | product line - | product line - | product line BioReagent |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form crystalline | form powder or crystals | form crystalline | form powder or crystals |
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signalword
Danger
hcodes
Hazard Classifications
Carc. 2 - Muta. 1B - Repr. 2
Clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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I can't find an expiration or use by date for the powder. Is it better to resuspend and freeze upon arrival or is it better to keep at 4deg until ready to resuspend and freeze?
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This product does not contain an expiration date or recommended retest date in its crystalline format. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one year warranty from the date of shipment.
This product should be placed in the proper storage temperature of 2-8°C upon arrival. Once reconstituted, the material should be stored at 2-8°C as well. For reconstitution instructions and stability, please see "Preparation Notes" section of the product page.
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