B2144
Boc-Tyr-D-Ala-Gly
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About This Item
Fórmula empírica (notación de Hill):
C19H27N3O7
Número de CAS:
Peso molecular:
409.43
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
storage temp.
−20°C
SMILES string
CC(NC(=O)C(Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(O)=O
Biochem/physiol Actions
Boc-Tyr-D-Ala-Gly is an N-terminal protected tripeptides useful in solid phase peptide synthesis (Boc-SPPS). Boc-Tyr-D-Ala-Gly may be used in the synthesis of opioid activity containing peptides such as biphalin molecule, enkephalins and tetrapeptide hydrazide.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Nigel P Pedersen et al.
Journal of neurophysiology, 106(2), 731-740 (2011-05-20)
The rostral ventromedial medulla (RVM) is an important site of opioid actions and forms part of an analgesic pathway that projects to the spinal cord. The neuronal mechanisms by which opioids act within this brain region remain unclear, particularly in
Krisztina Csabafi et al.
Peptides, 32(8), 1656-1660 (2011-07-05)
The neuroendocrine and behavioral effects of Tyr-D-Ala-Gly-Phe-D-Nle-Arg-Phe (DADN), a more stable derivative of the endogenous opiate Met-enkephalin related peptide Met(5)-enkephalin-Arg(6)-Phe(7) were investigated in mice. The behavioral experiments consisted of monitoring the horizontal (square crossing) and vertical (rearing) locomotion in the
Claudia U Hjørringgaard et al.
Journal of peptide science : an official publication of the European Peptide Society, 18(3), 199-207 (2012-01-19)
Benzotriazole-based coupling reagents have dominated the last two decades of solid phase peptide synthesis. However, a growing interest in synthesizing complex peptides has stimulated the search for more efficient and low-cost coupling reagents, such as COMU which has been introduced
A molecular dynamics study on opioid activities of biphalin molecule.
Hsieh JY, Chiang TY, Chen JL, et al.
Journal of Molecular Biology, 17, 2455-2464 (2011)
M Schnölzer et al.
International journal of peptide and protein research, 40(3-4), 180-193 (1992-09-01)
Simple, effective protocols have been developed for manual and machine-assisted Boc-chemistry solid phase peptide synthesis on polystyrene resins. These use in situ neutralization [i.e. neutralization simultaneous with coupling], high concentrations (> 0.2 M) of Boc-amino acid-OBt esters plus base for
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