![[Ala1,3,11,15]-Endothelin 1](/deepweb/assets/sigmaaldrich/product/structures/257/425/5e642291-a643-4523-a7f1-65d3e6e51aa8/640/5e642291-a643-4523-a7f1-65d3e6e51aa8.png)
Product No. B150 is BQ123 sodium salt.
B150
BQ-123
≥99%, sodium salt, lyophilized powder
Sinónimos:
BQ123, Cyclo(D-Trp-D-Asp-Pro-D-Val-Leu)
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200 μG
MXP 3,235.00
1 MG
MXP 8,995.00
MXP 3,235.00
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200 μG
MXP 3,235.00
1 MG
MXP 8,995.00
About This Item
Fórmula empírica (notación de Hill):
C31H41N6O7 Na
Número de CAS:
Peso molecular:
632.68
Número MDL:
Código UNSPSC:
12352204
ID de la sustancia en PubChem:
NACRES:
NA.32
MXP 3,235.00
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Productos recomendados
Nivel de calidad
Ensayo
≥99%
Formulario
lyophilized powder
temp. de almacenamiento
−20°C
cadena SMILES
[H][C@@]12CCCN1C(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC2=O)C(C)C
InChI
1S/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)/t21-,22+,23+,24-,26+/m0/s1
Clave InChI
VYCMAAOURFJIHD-PJNXIOHISA-N
Información sobre el gen
human ... EDNRA(1909) , EDNRB(1910)
rat ... Ednra(24326) , Ednrb(50672)
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Amino Acid Sequence
cyclo-Asp-Pro-Val-Leu-Trp
Aplicación
BQ-123 has been used as a selective endothelin-A receptor antagonist to study its effects on tumor necrosis factor α (TNFα)-induced human airway smooth muscle cells (HASMCs) proliferation.[1] It is also used as endothelin-A receptor antagonist to study its effects on TNFα-induced granulocyte–macrophage colony-stimulating factor (GM-CSF) expression.[2]
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Certificados de análisis (COA)
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Los clientes también vieron
J Knobloch et al.
Thorax, 64(12), 1044-1052 (2009-10-24)
There is an urgent need to inhibit endothelin-1 (ET-1) induced chronic inflammatory processes in early stages of lung diseases in order to prevent untreatable irreversible stages often accompanied by lung fibrosis and pulmonary hypertension. Nothing is known about the airway
M Clozel et al.
Life sciences, 52(9), 825-834 (1993-01-01)
The aim of this study was to evaluate the role of endothelin and endothelin ETA receptor in the early cerebral vasoconstriction following subarachnoid hemorrhage (SAH) in the rat. SAH induced by injection of autologous blood in the cisterna magna reduced
F Cosentino et al.
Journal of cardiovascular pharmacology, 22 Suppl 8, S332-S335 (1993-01-01)
The present study was designed to determine whether an endothelinA (ETA)-receptor antagonist BQ-123 (cyclo[Dtrp, Dasp, pro-D-Val-Leu]) or an ET-converting enzyme inhibitor phosphoramidon may prevent development of cerebral vasospasm after subarachnoid hemorrhage (SAH). A "double hemorrhage" canine model of the disease
T D Warner et al.
British journal of pharmacology, 112(1), 207-213 (1994-05-01)
1. Endothelin-1 binds almost irreversibly to its receptors and causes prolonged vasoconstrictions. Here we have studied the reversal of established responses to ET-1 in vivo and in vitro by BQ-123, an ETA receptor-selective antagonist, and/or PD 145065, an ETA/ETB receptor
Elín I Magnúsdóttir et al.
Journal of neuroinflammation, 17(1), 123-123 (2020-04-24)
Itch is an unpleasant sensation that can be debilitating, especially if it is chronic and of non-histaminergic origin, as treatment options are limited. Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor that also has the ability to induce a burning, non-histaminergic
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Is Product B150 the free acid form of BQ-123, or is it a salt?
1 answer-
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How should Product B150, BQ-123, be dissolved?
1 answer-
This product is soluble in water (0.25mg/ml), yielding a clear colorless solution.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the solution stability for Product B150, BQ-123?
1 answer-
We do not perform any solution stability studies on Product B150, BQ-123. The following reference indicates that the product is stable in solution for 24 hours but no temperature was mentioned. Cardillo, C. et al., Hypertension, 33, 753-758 (1999). The following abstract indicates that BQ-123 was used in an osmotic pump for a 2 week treatment. Bonvollet, S. et al., A.J.P. - Heart, 266 (4), H1327-H1331 (1994).
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