A7111

Acepromazine maleate

≥98% (HPLC)

• Sinónimos: Acetopromazine maleate salt, 2-Acetyl-10-(3-dimethylaminopropyl)phenothiazine maleate salt, Acepromazine maleate salt
• Fórmula empírica (notación de Hill): C₁₉H₂₂N₂OS · C₄H₄O₄
• Número de CAS: 3598-37-6
• Peso molecular: 442.53
• Número CE: 222-748-9
• Número MDL: MFCD00082473
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329770915
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: protect from light
• color: yellow
• solubilidad: H₂O: >10 mg/mL
• temp. de almacenamiento: room temp
• cadena SMILES: OC(=O)\C=C/C(O)=O.CN(C)CCCN1c2ccccc2Sc3ccc(cc13)C(C)=O
• InChI: 1S/C19H22N2OS.C4H4O4/c1-14(22)15-9-10-19-17(13-15)21(12-6-11-20(2)3)16-7-4-5-8-18(16)23-19;5-3(6)1-2-4(7)8/h4-5,7-10,13H,6,11-12H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
• Clave InChI: FQRHOOHLUYHMGG-BTJKTKAUSA-N

Descripción

Aplicación

Acepromazine maleate has been used:

• as a component of anesthesia cocktail to test its effects on behavioral changes in rats[1]
• as a component of anesthesia cocktail to study its effects on lung resistance of rats[2]
• as an anti-psychotic pharmaceutical agent to study its cytotoxic effects on malignant glioma in glioblastoma (GBM) cells[3]

Acciones bioquímicas o fisiológicas

Acepromazine is a phenothiazine antipsychotic comonly used as a veterinary drug (horses, dogs and cats). The compound is an analogue antipsychotic drug chlorpromazine (#C8138). The drug is thought to block receptors of dopamine in the brain. Recently it was discover that the compound inhibits ABCG2 transported protein, which overexpression in tumors is associated with drug resistance.

Atypical neuroleptic.

Características y beneficios

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H301,H336
• Consejos de prudencia: P301 + P310 + P330
• Clasificaciones de peligro: Acute Tox. 3 Oral - STOT SE 3
• Órganos de actuación: Central nervous system
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable