A4111
2-AAPA hydrate
≥95% (HPLC)
Sinónimos:
R,R′-2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)phenylthiocarbamoylsulfanyl]propionic acid hydrate, S, S′-[1,4-Phenylenebis(iminocarbonothioyl)]bis[N-acetyl-L-Cysteine] hydrate
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5 MG
MXP 3,485.00
25 MG
MXP 13,397.00
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5 MG
MXP 3,485.00
25 MG
MXP 13,397.00
About This Item
Fórmula empírica (notación de Hill):
C18H22N4O6S4
Peso molecular:
518.65
Código UNSPSC:
12352200
NACRES:
NA.25
Productos recomendados
Nivel de calidad
Ensayo
≥95% (HPLC)
Formulario
powder
solubilidad
DMSO: 10 mg/mL, clear
temp. de almacenamiento
2-8°C
Descripción general
Acciones bioquímicas o fisiológicas
Abnormal thiol redox state (TRS) is involved in the pathogenesis of a variety of diseases, such as chronic heart disease and atherosclerosis, rheumatoid arthritis , AIDS , Parkinson disease, Alzheimer disease, etc. Thus there is a need for tools capable of regulating TRS. Glutathione reductase (GR) is a critical enzyme in the homeostasis of TRS. Thus selective GR inhibitor would be a valuable research tool in studying TRS-related processes. Carmustine (#C0400) an anticancer drug is commonly used as GR inhibitor (IC50~470 microM). 2-AAPA is novel, potent cell-penetrable GR inhibitor. The compound is quite selective. But small reduction of activity for GP and GST was observed at 0.1mM concentration of 2-AAPT.
Glutathione reductase (GR) is a critical enzyme in the homeostasis of cellular thiol redox state. 2-AAPA is potent, selective, cell-permeable GR inhibitor, a valuable research tool in studying processes related to thiol redox state. For example, it was used in a study of the relationship between thiol redox state and overall redox state. In addition to the expected decrease in GSH and increase in GSSG, 2-AAPA increased the ratios of NAD(P)H/NAD(P)+. Significant protein glutathionylation was also observed.
Potent cell-permeable irreversible glutathione reductase (GR) inhibitor
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
nwg
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Journal of Pharmaceutical and Biomedical Analysis, 48(5), 1375-1380 (2008)
Inhibition of reductase systems by 2-AAPA modulates peroxiredoxin oxidation and mitochondrial function in A172 glioblastoma cells
de S L F, et al.
Toxicology in vitro, 42(5), 273-280 (2017)
Luiz Felipe de Souza et al.
Toxicology in vitro : an international journal published in association with BIBRA, 42, 273-280 (2017-05-04)
Thiol homeostasis has a critical role in the maintenance of proper cellular functions and survival, being coordinated by the action of several reductive enzymes, including glutathione (GSH)/glutathione reductase (GR) and thioredoxin (Trx)/thioredoxin reductase (TrxR) systems. Here, we investigated the effects
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Aldo-keto reductases (AKRs) are responsible for the detoxification of harmful aldehydes. Due to the large number of isotypes, the physiological relevance of AKRs cannot be obtained using mRNA or protein quantification, but only through the use of enzymatic assays to
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