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Merck

A4056

Sigma-Aldrich

Amrinone

Sinónimos:

5-Amino-(3,4′-bipyridin)-6(1H)-one, Inamrinone

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About This Item

Fórmula empírica (notación de Hill):
C10H9N3O
Número de CAS:
Peso molecular:
187.20
EC Number:
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:

assay

≥98% (TLC)

Quality Level

form

powder

solubility

1 M NaOH: 100 mg/mL

storage temp.

2-8°C

SMILES string

NC1=CC(=CNC1=O)c2ccncc2

InChI

1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)

InChI key

RNLQIBCLLYYYFJ-UHFFFAOYSA-N

Gene Information

human ... PDE3A(5139)
rat ... Pde3a(50678)

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Biochem/physiol Actions

Simple, non-glycoside cardiotonic agent, possibly via its phosphodiesterase III (PDE-III) inhibitory action.[1] Independent of its cardiac effects, amrinone provides protection against ischemia-reperfusion injury in kidney,[2] liver,[3] and heart.[4]
Simple, non-glycoside cardiotonic agent, possibly via its phosphodiesterase III (PDE-III) inhibitory action.[1]

pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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M P Rechtman et al.
European journal of pharmacology, 402(3), 255-262 (2000-08-26)
We investigated the effects of amrinone on ischaemia-induced changes in myocardial function in isolated rat hearts. Isolated hearts from male Sprague-Dawley rats (150-275 g) were perfused with physiological salt solution at a constant flow rate. The effects of amrinone (30
Kazuo Komamura et al.
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 11 Suppl 1, S39-S42 (2008-04-17)
Phosphodiesterase (PDE) III inhibitor therapy is effective for treatment of acute decompensated heart failure (ADHF). Nevertheless, this drug is expensive than conventional inotropic agent dobutamine. We compared total medication costs of the patients treated with PDE III inhibitor amrinone therapy
Can Kucuk et al.
The Journal of surgical research, 151(1), 74-79 (2008-05-13)
During some surgical interventions, temporary occlusion of the hepatic blood supply may cause ischemia-reperfusion (IR) injury. Recent studies suggest that type 3 phosphodiesterase inhibitors may have a beneficial effect on liver IR injury. The aim of this study was to
Yoshihiro Ko et al.
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 15(5), 311-317 (2009-11-11)
Phosphodiesterase (PDE) III inhibitors have been reported in various cellular protective activities via the cyclic adenosine monophosphate (cAMP) pathway. We investigated the effects of amrinone on ischemia/reperfusion injury and intracellular calcium (Ca2+) handling if utilized as a component of terminal
Nuria Albet-Torres et al.
The Journal of biological chemistry, 284(34), 22926-22937 (2009-06-13)
Amrinone is a bipyridine compound with characteristic effects on the force-velocity relationship of fast skeletal muscle, including a reduction in the maximum shortening velocity and increased maximum isometric force. Here we performed experiments to elucidate the molecular mechanisms for these

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