The recommended product to use as a positive control substrate for product A2108, AURORA B, active, GST tagged human, is product SRP5205, MBP, GST tagged human.
A2108
AURORA B, active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinónimos:
AIK2, AIM1, ARK2, AURKB, AurB, IPL1, STK12
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NACRES:
NA.32
UNSPSC Code:
12352200
Specific activity:
162-219 nmol/min·mg
Assay:
≥70% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected Sf9 cells
recombinant
expressed in baculovirus infected Sf9 cells
product line
PRECISIO® Kinase
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
162-219 nmol/min·mg
mol wt
~68 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... AURKB(9212)
Biochem/physiol Actions
AURORA B is a member of the Aurora kinase family that associates with microtubules during chromosome movement and segregation. AURORA B localizes to the microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AURORA B inhibits the microtubule depolymerizing activity of mitotic centromere-associated kinesin (MCAK) by phosphorylating MCAK on Ser92.This phosphorylation also regulates MCAK translocalization from kinetochores to the centromere. AURORA B has been identified as a target for the development of new anticancer agents since inhibition of AURORA B gives rise to the more pronounced antiproliferative phenotype.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
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Este artículo | |||
|---|---|---|---|
| specific activity 162-219 nmol/min·mg | specific activity 62-84 nmol/min·mg | specific activity - | specific activity - |
| assay ≥70% (SDS-PAGE) | assay ≥70% (SDS-PAGE) | assay ≥90% (SDS-PAGE) | assay - |
| Gene Information human ... AURKB(9212) | Gene Information human ... AURKA(6790) | Gene Information human ... AURKA(6790) | Gene Information human ... AURKA(6790) |
| recombinant expressed in baculovirus infected Sf9 cells | recombinant expressed in baculovirus infected Sf9 cells | recombinant expressed in baculovirus infected Sf9 cells | recombinant - |
| form buffered aqueous glycerol solution | form buffered aqueous glycerol solution | form aqueous solution | form buffered aqueous solution |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in wet ice |
Clase de almacenamiento
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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What is an appropriate substrate to use as a positive control when testing product A2108, AURORA B, active, GST tagged human?
1 answer-
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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