A1737

A922500

• Fórmula empírica (notación de Hill): C₂₆H₂₄N₂O₄
• Número de CAS: 959122-11-3
• Peso molecular: 428.48
• Número MDL: MFCD12828780
• Código UNSPSC: 12352204
• NACRES: NA.77

Propiedades

• origen biológico: synthetic (organic)
• Ensayo: >95% (HPLC)
• Formulario: powder
• mol peso: M_w 428.5
• solubilidad: DMSO: 10 mg/mL, clear, colorless to greenish-yellow
• temp. de almacenamiento: −20°C
• cadena SMILES: N(c2ccc(cc2)c3ccc(cc3)C(=O)[C@H]4[C@@H](CCC4)C(=O)O)C(=O)Nc1ccccc1
• InChI: 1S/C26H24N2O4/c29-24(22-7-4-8-23(22)25(30)31)19-11-9-17(10-12-19)18-13-15-21(16-14-18)28-26(32)27-20-5-2-1-3-6-20/h1-3,5-6,9-16,22-23H,4,7-8H2,(H,30,31)(H2,27,28,32)/t22-,23-/m1/s1
• Clave InChI: BOZRFEQDOFSZBV-DHIUTWEWSA-N

Descripción

Aplicación

A922500 has been used in the inhibition of diacylglycerol acyltransferase (DGAT) in epithelial human breast cancer cell line (MDA-MB-231), digitonin-permeabilized human cancer cells, human myotubes and macrophages.

Acciones bioquímicas o fisiológicas

Diacylglycerol acyltransferase (DGAT-1) inhibitor; IC₅₀ 7 to 24 nM

The diacylglycerol acyltransferase (DGAT) 1 inhibitor A922500 was shown to effectively reduce postprandial serum triglyceride levels in rodents at concentrations of 0.03, 0.3 and 3 mg/kg. These results suggest A922500 may have beneficial effects in reducing the risk of cardiovascular disease.

Forma física

A922500 is supplied as a crystalline solid.

Nota de preparación

A stock solution may be made by dissolving the A922500 in the solvent of choice. A922500 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable