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61350

Sigma-Aldrich

TS-Link™ Bimane thiosulfate sodium salt

≥98.0% (HPCE)

Sinónimos:

Thiosulfuric acid S-{2-oxo-2-{[(2,5,6-trimethyl-1,7-dioxo-1H,7H-pyrazolo[1,2-a]pyrazol-3-yl)methyl]amino}ethyl}ester monosodium salt

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About This Item

Fórmula empírica (notación de Hill):
C12H14N3NaO6S2
Número de CAS:
852178-18-8
Peso molecular:
383.38
MDL number:
MFCD12912387
UNSPSC Code:
12352200
PubChem Substance ID:
329759443
NACRES:
NA.32

assay

≥98.0% (HPCE)

fluorescence

λex 386 nm; λem 480 nm in 0.1 M phosphate pH 7.0

suitability

corresponds for coupling to thiols

storage temp.

−20°C

SMILES string

[Na+].CC1=C(C)C(=O)N2N1C(CNC(=O)CSS([O-])(=O)=O)=C(C)C2=O

InChI

1S/C12H15N3O6S2.Na/c1-6-8(3)14-9(7(2)12(18)15(14)11(6)17)4-13-10(16)5-22-23(19,20)21;/h4-5H2,1-3H3,(H,13,16)(H,19,20,21);/q;+1/p-1

InChI key

CFJHROSVZGHNCG-UHFFFAOYSA-M

Application

TS-Link Bimane thiosulfate sodium salt is used to fluorescence label sulfhydryls found in proteins and other biomolecules such as glutathione. In contrast to the thioether bonds formed by maleimides and iodoacetamides, the disulfide bonds formed by TS-Link reagents are reversible — the TS-Link hapten or fluorophore can easily be removed using a reducing agent such as DTT or TCEP. TS-Link reagents are selective for thiols at neutral pH, whereas maleimides will react with other functional groups. TS-Link Bimane thiosulfate sodium salt may be used in comparison with other sulfhydryl coupling strategies.

Legal Information

TS-Link is a trademark of Life Technologies

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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