53886
Tn Antigen
≥99.0% (TLC), powder or crystals
Sinónimos:
GalNac-α-1-O-serine, O-[2-(Acetylamino)-2-deoxy-α-D-galactopyranosyl]-L-serine
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1 MG
MXP 8,431.00
MXP 8,431.00
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1 MG
MXP 8,431.00
About This Item
Fórmula empírica (notación de Hill):
C11H20N2O8
Número de CAS:
Peso molecular:
308.29
Número MDL:
Código UNSPSC:
12352204
ID de la sustancia en PubChem:
NACRES:
NA.32
MXP 8,431.00
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Nombre del producto
Tn Antigen, ≥99.0% (TLC)
Ensayo
≥99.0% (TLC)
Formulario
powder or crystals
temp. de almacenamiento
−20°C
cadena SMILES
CC(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@H](N)C(O)=O
InChI
1S/C11H20N2O8/c1-4(15)13-7-9(17)8(16)6(2-14)21-11(7)20-3-5(12)10(18)19/h5-9,11,14,16-17H,2-3,12H2,1H3,(H,13,15)(H,18,19)/t5-,6+,7+,8-,9+,11-/m0/s1
Clave InChI
REDMNGDGDYFZRE-WKWISIMFSA-N
Categorías relacionadas
Descripción general
Tn antigen is a truncated O-glycan, that is commonly noticed in colorectal cancer (CRC).[1] It is usually expressed at high levels in cancer cells.[2] Tn antigen is small in size and simple in structure. It has a non-physiological glycan structure in humans, hence it may be identified as foreign by the immune system.[3]
Acciones bioquímicas o fisiológicas
Tn antigen stimulates colorectal cancer metastasis through the activation of epithelial-mesenchymal transition, mediated by H-Ras.[1] It acts as a precursor to several significant complex O-glycans. Subpopulations of blood cells in all lineages carrying the Tn antigen results in a hematological disorder called Tn syndrome.[3]
Envase
Bottomless glass bottle. Contents are inside inserted fused cone.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Sensors (Basel, Switzerland), 19(24) (2019-12-11)
The study describes development of a glycan biosensor for detection of a tumor-associated antibody. The glycan biosensor is built on an electrochemically activated/oxidized graphene screen-printed electrode (GSPE). Oxygen functionalities were subsequently applied for covalent immobilization of human serum albumin (HSA)
Zhe Liu et al.
Journal of cellular and molecular medicine, 23(3), 2083-2092 (2019-01-15)
Tn antigen is a truncated O-glycan, frequently detected in colorectal cancer (CRC), but its precise role in CRC metastasis is not well addressed. Here we investigated the effects of Core 1 β3Gal-T specific molecular chaperone (Cosmc) deletion-mediated Tn antigen exposure
Tianbo Gao et al.
Biochemical and biophysical research communications, 521(2), 514-520 (2019-11-05)
Aberrant O-glycosylation truncates O-glycans and is known to be closely associated with colorectal cancer (CRC), a major gastrointestinal tumor. CD44 is one of the highly post-transcriptionally modified O-glycoproteins participating in a series of physiological and pathobiological processes. In this research
Sophie A Dusoswa et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(7), 3693-3703 (2020-02-06)
Glioblastoma is the most aggressive brain malignancy, for which immunotherapy has failed to prolong survival. Glioblastoma-associated immune infiltrates are dominated by tumor-associated macrophages and microglia (TAMs), which are key mediators of immune suppression and resistance to immunotherapy. We and others
Lenneke A M Cornelissen et al.
Frontiers in oncology, 10, 1622-1622 (2020-10-06)
Expression of the tumor-associated glycan Tn antigen (αGalNAc-Ser/Thr) has been correlated to poor prognosis and metastasis in multiple cancer types. However, the exact mechanisms exerted by Tn antigen to support tumor growth are still lacking. One emerging hallmark of cancer
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