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46121

Resorufin ethyl ether

suitable for fluorescence, ≥95% (UV)

Sinónimos:

7-Ethoxy-3H-phenoxazin-3-one, Ethoxyresorufin, O7-Ethylresorufin

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Tamaño de envaseSKUDisponibilidadPrecio
5 mg
Comprobar disponibilidad del carrito
MXP 11,874.00

Acerca de este artículo

Fórmula empírica (notación de Hill):
C14H11NO3
Número CAS:
5725-91-7
Peso molecular:
241.24
UNSPSC Code:
12161501
NACRES:
NA.32
PubChem Substance ID:
329757074
MDL number:
MFCD00037661
Beilstein/REAXYS Number:
225973

MXP 11,874.00

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Quality Level

100

assay

≥95% (UV)

form

solid

mp

223-225 °C (lit.)

solubility

DMF: soluble, DMSO: soluble, alcohols: soluble

fluorescence

λex 464 nm; λem 540 nm in methanol(lit.), λex 571 nm; λem 585 nm in dealkylase(lit.)

suitability

suitable for fluorescence

storage temp.

2-8°C

SMILES string

CCOc1ccc2N=C3C=CC(=O)C=C3Oc2c1.Fc4c(F)c(F)c(OC(=O)CNC(=O)OCC5c6ccccc6-c7ccccc57)c(F)c4F

InChI

1S/C23H14F5NO4.C14H11NO3/c24-17-18(25)20(27)22(21(28)19(17)26)33-16(30)9-29-23(31)32-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15;1-2-17-10-4-6-12-14(8-10)18-13-7-9(16)3-5-11(13)15-12/h1-8,15H,9-10H2,(H,29,31);3-8H,2H2,1H3

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Este artículo
E3763M1544B1532
Resorufin ethyl ether suitable for fluorescence, ≥95% (UV)

Sigma-Aldrich

46121

Resorufin ethyl ether

Resorufin ethyl ether ≥98% (TLC), powder

Sigma-Aldrich

E3763

Resorufin ethyl ether

Resorufin methyl ether

Sigma-Aldrich

M1544

Resorufin methyl ether

Resorufin benzyl ether CYP450 substrate

Sigma-Aldrich

B1532

Resorufin benzyl ether

assay

≥95% (UV)

assay

≥98% (TLC)

assay

≥98.0% (HPLC)

assay

≥98% (TLC)

solubility

DMF: soluble, alcohols: soluble, DMSO: soluble

solubility

chloroform: 9.80-10.20 mg/mL, clear, orange

solubility

dichloromethane: 0.95-1.05 mg/mL, clear, orange to very deep orange

solubility

chloroform: 9.80-10.20 mg/mL, clear, orange

suitability

suitable for fluorescence

suitability

suitable for fluorescence

suitability

-

suitability

-

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

form

solid

form

powder

form

powder

form

powder

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

Application

7-Ethoxyresorufin (7-ER) is a substrate used in environmental toxicology studies to monitor ethoxyresorufin-O-deethylase catalytic activity in the EROD assay. The EROD assay monitors the induction of the xenobiotic-metabolizing enzyme cytochrome P-450 (CYP) 1A1 and is a widely used biomarker for exposure of wildlife to substances that bind the aryl hydrocarbon (Ah) receptor. It provides evidence of receptor-mediated induction of cytochrome P450-dependant monooxygenases (the CYP1A subfamily specifically) by xenobiotic chemicals.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Dealkylase substrate for the microfluorimetric analysis of microsomal cytochrome P-450[1][2]

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
BCCP0264
BCCH6416
BCCD1452
BCBW8237
BCBT3131

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Gillian E Manning et al.
Toxicology and applied pharmacology, 266(1), 38-47 (2012-11-13)
Avian-specific toxic equivalency factors (TEFs) were developed by the World Health Organization to simplify environmental risk assessments of dioxin-like compounds (DLCs), but TEFs do not account for differences in the toxic and biochemical potencies of DLCs among species of birds.
M D Burke et al.
The Biochemical journal, 212(1), 15-24 (1983-04-15)
A fluorescence-microscopic method has been developed for measurement of the intracellular kinetics of the cytochrome P-450 reaction, ethoxyresorufin O-de-ethylation, in individual hepatocytes in unfixed non-frozen liver sections obtained from control or 3-methylcholanthrene-pretreated mice. De-ethylation was enhanced in the presence of
J J Whyte et al.
Critical reviews in toxicology, 30(4), 347-570 (2000-08-24)
This review compiles and evaluates existing scientific information on the use, limitations, and procedural considerations for EROD activity (a catalytic measurement of cytochrome P4501A induction) as a biomarker in fish. A multitude of chemicals induce EROD activity in a variety
Markus Brinkmann et al.
Aquatic toxicology (Amsterdam, Netherlands), 128-129, 13-24 (2012-12-25)
Increasing frequency and intensity of flood events are major concerns in the context of climate change. In addition to the direct hydrological implications of such events, potential ecotoxicological impacts are of increasing interest. It is vital to understand mechanisms of
T E M Parente et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 150(2), 252-260 (2009-05-23)
We investigated the presence and inducibility of CYP1A in suckermouth catfish (Hypostomus affinis and Hypostomus auroguttatus, Loricariidae), tilapia (Oreochromis niloticus, Cichlidae) and mice (Mus musculus, Muridae). Alkoxyresorufin-O-dealkylases (EROD, MROD, PROD and BROD) were detected and proved to be inducible (beta-naphthoflavone
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SKUGTIN
46121-25MG-F04061833277218
46121-5MG-F04061832344355

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