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Merck

42597

Supelco

3′-Deoxythymidine 5′-triphosphate sodium salt solution

BioChemika, puriss. p.a., suitable for MALDI-MS, ≥98.0% (HPLC)

Sinónimos:

2′,3′-Dideoxythymidine 5′-triphosphate, ddTTP

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About This Item

Fórmula empírica (notación de Hill):
C10H16N2NaO13P3
Número de CAS:
Peso molecular:
488.15
MDL number:
UNSPSC Code:
41116105
PubChem Substance ID:

product line

BioChemika

grade

puriss. p.a.

assay

≥98.0% (HPLC)

concentration

10.0-11.0 mmol/L (UV)

technique(s)

MALDI-MS: suitable

impurities

≤1.5% ddNDP (HPLC)

suitability

corresponds for UV test

storage temp.

−20°C

SMILES string

[Na+].CC1=CN([C@H]2CC[C@@H](COP([O-])(=O)OP(O)(=O)OP(O)(O)=O)O2)C(=O)NC1=O

InChI

1S/C10H17N2O13P3.Na/c1-6-4-12(10(14)11-9(6)13)8-3-2-7(23-8)5-22-27(18,19)25-28(20,21)24-26(15,16)17;/h4,7-8H,2-3,5H2,1H3,(H,18,19)(H,20,21)(H,11,13,14)(H2,15,16,17);/q;+1/p-1/t7-,8+;/m0./s1

InChI key

QJSZKDPCBDXBCK-KZYPOYLOSA-M

General description

3′-Deoxythymidine 5′-triphosphate sodium (ddTTP) is a sugar-modified dTTP analogue which is selective inhibitor of HIV-associated reverse transcriptase (HIV-RT). It is also seen to inhibit the activity of DNA polymerase α.

Packaging

packaging : 1 μmol (approx. 91-100 μL)

Related product

Referencia del producto
Descripción
Precios

replaced by

Referencia del producto
Descripción
Precios

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificados de análisis (COA)

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Sylvia Steininger et al.
Nucleic acids research, 38(6), 1853-1865 (2009-12-31)
The Mre11/Rad50/Xrs2 (MRX) complex in Saccharomyces cerevisiae has well-characterized functions in DNA double-strand break processing, checkpoint activation, telomere length maintenance and meiosis. In this study, we demonstrate an involvement of the complex in the base excision repair (BER) pathway. We
Elena N Ilina et al.
Frontiers in microbiology, 4, 186-186 (2013-07-13)
Spectinomycin remains a useful reserve option for therapy of gonorrhea. The emergence of multidrug-resistant Neisseria gonorrhoeae strains with decreased susceptibility to cefixime and to ceftriaxone makes it the only medicine still effective for treatment of gonorrhea infection in analogous cases.
Inhibition of the activity of DNA polymerase alpha by 2',3'-dideoxythymidine 5'-triphosphate.
K Ono et al.
Biochemical and biophysical research communications, 88(4), 1255-1262 (1979-06-27)
Kevin A Fiala et al.
Nucleic acids research, 36(6), 1990-2001 (2008-02-16)
Our previous publication shows that Sulfolobus solfataricus Dpo4 utilizes an 'induced-fit' mechanism to select correct incoming nucleotides at 37 degrees C. Here, we provide a comprehensive report elucidating the kinetic mechanism of a DNA polymerase at a reaction temperature higher
Sascha Tierling et al.
Epigenetics & chromatin, 3(1), 12-12 (2010-06-08)
DNA methylation changes are widely used as early molecular markers in cancer detection. Sensitive detection and classification of rare methylation changes in DNA extracted from circulating body fluids or complex tissue samples is crucial for the understanding of tumor etiology

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