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42129

Lathosterolamide MGI-39

≥97.0% (HPLC)

Sinónimos:

(3S,20S)-20-N-(2-Methylpropyl)carbamoylpregn-7-en-3β-ol, (3S,20S)-3β-Hydroxy-N-(2-methylpropyl)-7-pregnene-20-carboxamide, Lathosterol Oxidase Inhibitor

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About This Item

Fórmula empírica (notación de Hill):
C26H43NO2
Número de CAS:
1058719-76-8
Peso molecular:
401.63
MDL number:
MFCD12912383
UNSPSC Code:
12352204
PubChem Substance ID:
329756194

biological source

synthetic

assay

≥97.0% (HPLC)

form

crystals and lumps

storage temp.

2-8°C

SMILES string

CC(C)CNC(=O)[C@@H](C)[C@H]1CC[C@H]2C3=CC[C@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C26H43NO2/c1-16(2)15-27-24(29)17(3)21-8-9-22-20-7-6-18-14-19(28)10-12-25(18,4)23(20)11-13-26(21,22)5/h7,16-19,21-23,28H,6,8-15H2,1-5H3,(H,27,29)/t17-,18-,19-,21+,22-,23-,25-,26+/m0/s1

InChI key

HUMXZYXRXDDZOG-LFZVSNMSSA-N

Biochem/physiol Actions

Lathosterolamide MGI-39 is an inhibitor of lathosterol oxidase which converts 5-α-cholest-7-en-3-β-ol to cholesta-5,7-dien-3β-ol.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H302,H400

pcodes

P273

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Martin Giera et al.
Steroids, 73(3), 299-308 (2008-01-01)
Inhibition of cholesterol biosynthesis offers the opportunity for treatment of cardiovascular diseases. Numerous enzymes are involved in the post-squalene part of this biosynthesis, and selective inhibitors for almost all of the enzymes involved there have been described in literature. The
Carolina C Sánchez-Martín et al.
Cancer research, 67(7), 3379-3386 (2007-04-06)
Cholesterol metabolism is particularly active in malignant, proliferative cells, whereas cholesterol starvation has been shown to inhibit cell proliferation. Inhibition of enzymes involved in cholesterol biosynthesis at steps before the formation of 7-dehydrocholesterol has been shown to selectively affect cell
Ralf Klingenstein et al.
Journal of neurochemistry, 98(3), 748-759 (2006-06-06)
Prion diseases are invariably fatal, neurodegenerative diseases transmitted by an infectious agent, PrPSc, a pathogenic, conformational isoform of the normal prion protein (PrPC). Heterocyclic compounds such as acridine derivatives like quinacrine abolish prion infectivity in a cell culture model of
Ken'ichi Hagiwara et al.
Biological & pharmaceutical bulletin, 30(4), 835-838 (2007-04-06)
In prion diseases, the normal cellular form of prion protein (PrP(C)) is converted into the disease-associated isoforms (PrP(Sc)) which accumulate in the infected tissues. Although the precise mechanism of this conversion remains unsolved, drugs of various categories have been reported
Carlos Fernández et al.
Journal of lipid research, 46(5), 920-929 (2005-02-03)
Cholesterol is a major lipid component of the plasma membrane in animal cells. In addition to its structural requirement, cholesterol is essential in cell proliferation and other cell processes. The aim of the present study was to elucidate the stringency
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