21872
(2-Carboxyethyl)-β-cyclodextrin sodium salt
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About This Item
Fórmula empírica (notación de Hill):
C51H76Na3O41
Peso molecular:
1414.09
Número MDL:
Código UNSPSC:
12352201
NACRES:
NA.25
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Formulario
solid
actividad óptica
[α]20/D +129±6°, c = 1% in H2O
impurezas
≤10% acidic form
~5% water
solubilidad
H2O: 50 mg/mL, clear, colorless
temp. de almacenamiento
room temp
Descripción general
(2-Carboxyethyl)-β-cyclodextrin sodium is a derivative of β-cyclodextrin, typically used to enhance the properties of the latter such as stability and water solubility. β-cyclodextrin has garnered increased research attention due to its potential application as host-guest inclusion complex used in the pharmaceutical industry and as antibacterial material utilized in food and pharmacy.[1]
Aplicación
(2-Carboxyethyl)-β-cyclodextrin sodium salt may be used:
- As a chiral selector for the enantioseparation of cinacalcet impurities[2] and fenamiphos pesticide[3] by capillary zone electrophoresis and 31P nuclear magnetic resonance spectroscopy (31P NMR), respectively.
- To form an inclusion complex with carvacrol for subsequent use in the antibacterial multilayer construction with chitosan, loaded onto poly(L-lactic acid) (PLLA).[1]
Cyclodextrins (CD) are cyclic oligosaccharides composed of D-glucose units connected via α(1→4) glycosidic bonds. Common cyclodextrins contain six (α-CD); seven (β-CD) or eight (gamma-CD) D-glucose units. Cyclodextrins are sometimes derivitized through esterification at positions two, three and/or six.(2-Carboxyethyl)-β-cyclodextrin and other negative charge derivitized cyclodextrins are used in chiral recognition and resolution of cationic racemic mixtures of enantiomers using capillary electrophoresis.
Nota de análisis
average degree of substitution, DS ~3
Otras notas
To gain a comprehensive understanding of our extensive range of Oligosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Benedetta Pasquini et al.
Journal of chromatography. A, 1568, 205-213 (2018-07-15)
A capillary electrophoresis method for the simultaneous determination of the enantiomeric purity and of impurities of the chiral calcimimetic drug cinacalcet hydrochloride has been developed following Quality by Design principles. The scouting phase was aimed to select the separation operative
B Koppenhoefer et al.
Journal of chromatography. A, 875(1-2), 135-161 (2000-06-06)
This is a selected review, highlighting our results obtained in an extended screening program ("The German-Chinese Drug Screening Program"), with a focus on a set of original data obtained with heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin (TM-beta-CD) as the chiral solvating agent (CSA). The enantioseparation
L J Jin et al.
Journal of chromatography. B, Biomedical sciences and applications, 708(1-2), 257-266 (1998-07-08)
The enantiomeric separation of some racemic anti-histamines and anti-malarials, namely (+/-)-pheniramine, (+/-)-brompheniramine, (+/-)-chlorpheniramine, (+/-)-doxylamine, and (+/-)-chloroquine, was investigated by capillary zone electrophoresis. The enantiomeric separation of five compounds was obtained by addition of approximately 7 mM (1%, w/v) sulfated-beta-cyclodextrin into
Antibacterial multilayer of chitosan and (2-carboxyethyl)-beta-cyclodextrin onto polylactic acid (PLLA)
Andrade-Del O, et al.
Food Hydrocolloids, 88, 228-236 (2019)
E Albers et al.
Critical reviews in therapeutic drug carrier systems, 12(4), 311-337 (1995-01-01)
The current cyclodextrin (CD) literature is reviewed concerning synthesis, characterization, and pharmaceutical relevant applications of CD derivatives. Although natural CDs have been used extensively to improve pharmaceutical properties, the effects of chemically modified CDs on the solubility, dissolution rate, and
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