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Certificado de origen (COO)/COA

156R-9

CD56 (MRQ-42) Rabbit Monoclonal Antibody

Name: CD56 (MRQ-42) Rabbit Monoclonal Antibody
Brand: SIGMA

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About This Item

Código UNSPSC:

12352203

NACRES:

NA.41

origen biológico

rabbit

Nivel de calidad

100
500

conjugado

unconjugated

forma del anticuerpo

culture supernatant

tipo de anticuerpo

primary antibodies

clon

MRQ-42, monoclonal

descripción

For In Vitro Diagnostic Use in Select Regions (See Chart)

Formulario

buffered aqueous solution

reactividad de especies

human

envase

vial of 0.1 mL concentrate (156R-94)
vial of 0.5 mL concentrate (156R-95)
bottle of 1.0 mL predilute (156R-97)
vial of 1.0 mL concentrate (156R-96)
bottle of 7.0 mL predilute (156R-98)

fabricante / nombre comercial

Cell Marque^®

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotipo

IgG1

control

neuroblastoma

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

visualización

membranous

Información sobre el gen

human ... NCAM1(4684)

Categorías relacionadas

Cell Marque

Cell Marque™ Primary Antibodies

Clinical & Diagnostics

Descripción general

CD56, also known as a neural cell adhesion molecule (NCAM), is a calcium-independenthomophilic binding protein that belongs to a group of cell adhesion molecules includingcadherins, selectins, and integrins. CD56 is involved in cell-cell adhesion of neural cellsduring embryogenesis and is expressed in most neuroectodermally derived tissues. Innormal tissue, anti-CD56 labels neurons, glia, Schwann cells, NK (natural killer) cells, and asubset of T-cells. CD56 expression can be seen in most NK cell neoplasms,4 and is frequentlyused to identify neoplasms with neuroendocrine differentiation.

Calidad

IVD

RUO

Ligadura / enlace

CD56 Positive Control Slides, Product No. 156S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparación

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Otras notas

For Technical Service please contact: 800-665-7284 or email: [email protected]

Información legal

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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NCAM and lung cancer.

R Michalides et al.

International journal of cancer. Supplement = Journal international du cancer. Supplement, 8, 34-37 (1994-01-01)

The presence of the neural cell adhesion molecule, NCAM, is indicative for a poor prognosis in lung-cancer patients. Using MAb 735, we have investigated the expression of polysialic acid, PSA, on NCAM in a spectrum of neuro-endocrine lung tumors, ranging

Aggressive Epstein-Barr virus-associated, CD8+, CD30+, CD56+, surface CD3-, natural killer (NK)-like cytotoxic T-cell lymphoma.

Jianguo Tao et al.

The American journal of surgical pathology, 26(1), 111-118 (2002-01-05)

We report an unusual case of aggressive natural killer (NK)-like cytotoxic T-cell lymphoma in a previously healthy immunocompetent West African male. He presented with a fever of unknown origin, subsequently developed erythematous skin nodules, generalized lymphadenopathy, and hepatosplenomegaly, and then

Utility of 123C3 monoclonal antibody against CD56 (NCAM) for the diagnosis of small cell carcinomas on paraffin sections.

O Kaufmann et al.

Human pathology, 28(12), 1373-1378 (1998-01-07)

CD56 is immunohistochemically detectable in virtually all small cell carcinomas on frozen sections. The authors retrospectively tested the usefulness of the monoclonal antibody 123C3 against CD56 to differentiate pulmonary and extrapulmonary small cell carcinomas from nonneuroendocrine non-small cell carcinomas by

Hot spots of antigenicity in the neural cell adhesion molecule NCAM.

R Gerardy-Schahn et al.

International journal of cancer. Supplement = Journal international du cancer. Supplement, 8, 38-42 (1994-01-01)

Monoclonal antibodies (MAbs) ranked together as small-cell-lung-cancer (SCLC) Cluster I MAbs are directed against the neural cell adhesion molecule NCAM (CD 56) and have been shown to be useful reagents in SCLC diagnosis and therapy. We analyzed the epitopes recognized

Expression of neural cell adhesion molecule-related sialoglycoprotein in small cell lung cancer and neuroblastoma cell lines H69 and CHP-212.

C E Moolenaar et al.

Cancer research, 50(4), 1102-1106 (1990-02-15)

Monoclonal antibodies (MAbs) 123C3 and 123A8 generated against a membrane preparation of a small cell lung carcinoma (SCLC) specimen recognize not only SCLC and bronchial carcinoids but also a significant portion of non-small cell lung carcinomas (non-SCLC) of various histological

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