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101R-1

Sigma-Aldrich

CD1a (EP3622) Rabbit Monoclonal Primary Antibody

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41
En este momento no podemos mostrarle ni los precios ni la disponibilidad

origen biológico

rabbit

Nivel de calidad

100
500

conjugado

unconjugated

forma del anticuerpo

culture supernatant

tipo de anticuerpo

primary antibodies

clon

EP3622, monoclonal

descripción

For In Vitro Diagnostic Use in Select Regions (See Chart)

Formulario

buffered aqueous solution

reactividad de especies

human

envase

vial of 0.1 mL concentrate (101R-14)
vial of 0.5 mL concentrate (101R-15)
bottle of 1.0 mL predilute (101R-17)
pkg of 1.0 mL concentrate (101R-16)
bottle of 7.0 mL predilute (101R-18)

fabricante / nombre comercial

Cell Marque®

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotipo

IgG1

control

skin, thymus

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

visualización

membranous

Información sobre el gen

human ... CD1A(909)

Descripción general

CD1a is a non-polymorphic, major histocompatibility complex, class I-related cell surface glycoprotein (45 to 55 kDa), and is expressed in association with β-microglobulin.[1] In normal tissues, anti-CD1a reacts with cortical thymocytes, Langerhans cells, interdigitating cells, and rare antigen-presenting cells of the lymph node.[2] CD1a positivity has also been seen in Langerhans cell histiocytosis (histiocytosis X)[3], and a subset of pre-T lymphoblastic lymphoma/leukemia (cortical T LBL/L).[4]

Calidad


IVD

IVD

IVD

RUO

Ligadura / enlace

CD1a Positive Control Slides, Product No. 101S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparación

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Otras notas

For Technical Service please contact: 800-665-7284 or email: [email protected]

Información legal

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Xin Han et al.
American journal of clinical pathology, 127(4), 528-544 (2007-03-21)
Session 4 of the 2005 Society of Hematopathology/European Association for Haematopathology Workshop focused on case presentations of precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma (pre-T ALL/LBL) and acute biphenotypic leukemia. Pre-T ALL represents approximately 15% of childhood and 25% of adult
Samir Dalia et al.
Cancer control : journal of the Moffitt Cancer Center, 21(4), 322-327 (2014-10-14)
Rosai-Dorfman disease (RDD) is a rare, nonmalignant clinical entity characterized by a group of clinical symptoms and characteristic pathological features. Articles that reviewed tumor biology, clinical features, pathology, and treatment for RDD were identified in a search of the literature
L Krenács et al.
The Journal of pathology, 171(2), 99-104 (1993-10-01)
The immunoreactivity of a CD1a monoclonal antibody (MAb), denoted 010, was investigated by means of the streptavidin-biotin-peroxidase method in formalin-fixed and paraffin-embedded tissues from 47 cases. The samples comprised reactive lymphoid proliferations of skin, tonsil, and lymph node including dermatopathic
J F Emile et al.
The American journal of surgical pathology, 19(6), 636-641 (1995-06-01)
The histological and immunohistochemical findings of 34 biopsy specimens from patients with Langerhans' cell histiocytosis (LCH) are reported, with special emphasis on the findings with CD1a mouse monoclonal antibody (MAb) O10 using paraffin-embedded material. Eighteen patients were treated in an
Catherine E Angel et al.
Blood, 113(6), 1257-1267 (2008-11-07)
Professional antigen-presenting cells (APCs) are sentinel cells of the immune system that present antigen to T lymphocytes and mediate an appropriate immune response. It is therefore surprising that knowledge of the professional APCs in human lymph nodes is limited. Using

Questions

  1. Can the CD1a (EP3622) Rabbit Monoclonal Primary Antibody be used with frozen human tissue? are there any similar products that can be used on frozen tissue?

    1 answer
    1. There is not any data on how this or any of our antibodies will work on frozen tissue. They were only used to run testing on 10% NBF processed tissue. It might be worth purchasing the smallest size and testing it to see if it would work for your conditions.

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