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01810

Sigma-Aldrich

Cycloheximide

≥95% (HPLC)

Sinónimos:

3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A

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1 G
MXP 2,258.00
5 G
MXP 5,868.00

MXP 2,258.00

Disponible para envío el07 de abril de 2025Detalles

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1 G
MXP 2,258.00
5 G
MXP 5,868.00

About This Item

Fórmula empírica (notación de Hill):
C15H23NO4
Número de CAS:
66-81-9
Peso molecular:
281.35
Beilstein:
88868
Número CE:
200-636-0
Número MDL:
MFCD00082346
Código UNSPSC:
51102829
ID de la sustancia en PubChem:
329747360
NACRES:
NA.85

MXP 2,258.00

Disponible para envío el07 de abril de 2025Detalles

Solicitar un pedido a granel

origen biológico

microbial

Ensayo

≥95% (HPLC)

Formulario

powder or crystals

color

white to light beige

espectro de actividad antibiótica

fungi
yeast

Modo de acción

protein synthesis | interferes

cadena SMILES

N1C(=O)CC(CC1=O)C[C@@H](O)[C@@H]2C[C@H](C[C@@H](C2=O)C)C

InChI

1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1

Clave InChI

YPHMISFOHDHNIV-FSZOTQKASA-N

Información sobre el gen

human ... FKBP1A(2280) , PIN1(5300)

Categorías relacionadas

Aplicación

Cyclohexamide (CHX) is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis[1][2] for detection of short-lived proteins, super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. It has been shown to selectively clear macrophages in atherosclerotic plaques,[3] activate cumulus-free equine oocytes,[4] and to have neuroprotective properties.[5]

Acciones bioquímicas o fisiológicas

Cyclohexamide inhibits protein biosynthesis in eukaryotic cells by binding with the 80S ribosome.[6]
Cycloheximide (CHX) is an antibiotic produced by Strptomyces sp.. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Envase

1G, 5G

Otras notas

Conditions for safe storage, including any incompatibilities. Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Palabra de señalización

Danger

Frases de peligro

H300,H341,H360D,H411

Clasificaciones de peligro

Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B

Código de clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
0000430586
0000430586
0000422040
0000422040
0000332154

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Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

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¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Tumor-suppressive functions of long-chain acyl-CoA synthetase 4 in gastric cancer
Ye X, et al.
IUBMB Life, 68(4), 320-327 (2016)
K Furukawa et al.
The Journal of cell biology, 136(5), 1137-1149 (1997-03-10)
The ability of the protein synthesis inhibitor cycloheximide (CHX) to prevent neuronal death in different paradigms has been interpreted to indicate that the cell death process requires synthesis of "killer" proteins. On the other hand, data indicate that neurotrophic factors
Neuronal activity regulates DROSHA via autophagy in spinal muscular atrophy
GG Ines do Carmo, et al.
Scientific Reports, 8(1), 7907-7907 (2018)
Valerie Croons et al.
The Journal of pharmacology and experimental therapeutics, 320(3), 986-993 (2006-12-01)
Macrophages are an essential component of unstable atherosclerotic plaques and play a pivotal role in the destabilization process. We have demonstrated previously that local delivery of the mammalian target of rapamycin (mTOR) inhibitor everolimus selectively clears macrophages in rabbit plaques.
Y H Choi et al.
Reproduction (Cambridge, England), 122(1), 177-183 (2001-06-27)
Two different culture media (TCM-199 and follicular fluid), two activation treatments (10 and 50 micromol calcium ionophore l(-1)) and three culture periods with cycloheximide were evaluated to find effective culture conditions for activation of cumulus-free equine oocytes. Oocytes were collected
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Questions

  1. What is the minimum shelf life of the product that should be considered if the certificate of analysis only indicates the quality release date?

    1 answer

    1. The product specification sheet for this product contains a recommended retest date period of two years after the quality release date. A recommended retest date is the period of time during which the product is expected to remain within established stability specifications, provided that it has been stored under defined conditions. After the Retest Date, product samples should be examined to ensure that the product is still in compliance with the established specifications. For more information, you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management/quality-services

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