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Merck

PHR1158

Supelco

Benzocaine

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

4-Aminobenzoic acid ethyl ester, Ethyl 4-aminobenzoate

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1 G
MXP 2,526.00

MXP 2,526.00


Disponible para envío el08 de abril de 2025Detalles


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1 G
MXP 2,526.00

About This Item

Fórmula empírica (notación de Hill):
C9H11NO2
Número de CAS:
Peso molecular:
165.19
Beilstein:
638434
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24

MXP 2,526.00


Disponible para envío el08 de abril de 2025Detalles


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grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

Agency

traceable to USP 1054000

familia API

benzocaine

CofA

current certificate can be downloaded

técnicas

HPLC: suitable
gas chromatography (GC): suitable

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-30°C

cadena SMILES

CCOC(=O)c1ccc(N)cc1

InChI

1S/C9H11NO2/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6H,2,10H2,1H3

Clave InChI

BLFLLBZGZJTVJG-UHFFFAOYSA-N

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Descripción general

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Benzocaine is an ester-type local anesthetic, able to induce pain relief. It is used extensively in topical, mucosal and dermal formulations.[1]

Aplicación

Benzocaine may be used as a pharmaceutical reference standard for the determination of the analyte in bioadhesive gel,[1] pharmaceutical formulations[2] and channel catfish tissues[3] by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Values of analytes vary lot to lot.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAA6506 in the slot below. This is an example certificate only and may not be the lot that you receive.

Productos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Skin Sens. 1

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

233.6 °F

Punto de inflamabilidad (°C)

112 °C


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Certificados de análisis (COA)

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Separation and simultaneous high-performance liquid chromatographic determination of benzocaine and benzyl benzoate in a pharmaceutical preparation.
Gigante B, et al.
Journal of Chromatography A, 549(5), 217-220 (1991)
A new validated method for the simultaneous determination of benzocaine, propylparaben and benzyl alcohol in a bioadhesive gel by HPLC.
Perez-Lozano P, et al.
Journal of Pharmaceutical and Biomedical Analysis, 39(5), 920-927 (2005)
A Szoke et al.
Journal of pharmaceutical and biomedical analysis, 16(1), 69-75 (1998-02-03)
Methods for extraction and gradient HPLC quantification were developed for benzocaine (BZ) and three of its metabolites to be used in conjunction with a reverse isotope technique. The metabolites were p-aminobenzoic acid (PABA), acetyl-p-aminobenzoic acid (AcPABA) and acetylbenzocaine (AcBZ). The
Sherry I Bame et al.
American journal of preventive medicine, 43(6 Suppl 5), S435-S442 (2012-11-28)
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The crystallization kinetics of various active pharmaceutical ingredient/polyethylene glycol (API/PEG) solid dispersions has been investigated using wide-angle X-ray diffraction (XRD) and Raman spectroscopy. APIs with different physicochemical properties and crystallization tendency were employed to form solid dispersions with PEG. The

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