This product is soluble in ethanol, methanol, acetone, ether, acetonitrile, and chloroform. This product is a reference standard intended for use in laboratory chemical testing, primarily per compendial monographs. This product may not be used for therapeutic or diagnostic purposes in humans or animals. Please contact your regional Technical Service group for assistance with specific applications.
PHR1092
Cyclosporine
Pharmaceutical Secondary Standard; Certified Reference Material
Sinónimos:
Cyclosporin A, Antibiotic S 7481F1, Cyclosporine
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500 MG
MXP 5,592.00
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500 MG
MXP 5,592.00
About This Item
Fórmula empírica (notación de Hill):
C62H111N11O12
Número de CAS:
Peso molecular:
1202.61
Beilstein:
3647785
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24
Productos recomendados
grado
certified reference material
pharmaceutical secondary standard
Nivel de calidad
Agency
traceable to Ph. Eur. C2163000
traceable to USP 1158504
familia API
cyclosporine
CofA
current certificate can be downloaded
técnicas
HPLC: suitable
gas chromatography (GC): suitable
aplicaciones
pharmaceutical (small molecule)
Formato
neat
temp. de almacenamiento
-10 to -25°C
cadena SMILES
CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
InChI
1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
Clave InChI
PMATZTZNYRCHOR-CGLBZJNRSA-N
Información sobre el gen
human ... PPIA(5478)
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Descripción general
Cyclosporine is a lipophilic immunosuppressive peptide with antifungal and anti-inflammatory properties.[1] It selectively inhibits the production of cytokines involved in T-lymphocyte activation in response to antigen stimulation.[2] It is widely used to prevent transplanted organ rejection and for the treatment of various autoimmune diseases.[3]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Aplicación
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Cyclosporine may be used as a reference standard for the determination of cyclosporine in biological samples by high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method.[4]
Cyclosporine may be used as a reference standard for the determination of cyclosporine in biological samples by high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method.[4]
Acciones bioquímicas o fisiológicas
A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.
Potent immunosuppressant; inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα; blocks cytochrome c release from mitochondria.
Nota de análisis
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Otras notas
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Nota al pie de página
To see an example of a Certificate of Analysis for this material enter LRAB3757 in the slot below. This is an example certificate only and may not be the lot that you receive.
Producto relacionado
Referencia del producto
Descripción
Precios
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 4 Oral - Carc. 1B - Repr. 1B
Código de clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Clase de riesgo para el agua (WGK)
WGK 3
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Certificados de análisis (COA)
Lot/Batch Number
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This material is in powder form. The purity is typically greater than 99% and is reported in the product Certificate of Analysis. Please see the link below to review a sample or lot specific Certificate.
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