PHR1084

1,1-Dimetilbiguanida hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinónimos: Metformina
• Fórmula lineal: NH₂C(=NH)NHC(=NH)N(CH₃)₂ · HCl
• Número de CAS: 1115-70-4
• Peso molecular: 165.62
• Número CE: 214-230-6
• Número MDL: MFCD00012582
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329823106
• NACRES: NA.24

Propiedades

• grado: certified reference material; pharmaceutical secondary standard
• Nivel de calidad: 300
• Agency: traceable to Ph. Eur. M0605000; traceable to USP 1396309
• familia API: metformin
• CofA: current certificate can be downloaded
• envase: pkg of 500 mg
• técnicas: HPLC: suitable; gas chromatography (GC): suitable
• mp: 223-226 °C (lit.)
• aplicaciones: pharmaceutical (small molecule)
• Formato: neat
• temp. de almacenamiento: 2-8°C
• cadena SMILES: Cl[H].CN(C)C(=N)NC(N)=N
• InChI: 1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
• Clave InChI: OETHQSJEHLVLGH-UHFFFAOYSA-N

Descripción

Descripción general

Metformin is a biguanide hypoglycaemic agent[1] and an oral antidiabetic medication[2] widely used in the treatment of type 2 diabetes.[3] It is effective in glycemic control and decreases the intestinal absorption of glucose,[1] without the problem of serious lactic acidosis.[3]

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicación

Metformin hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations[1][2] using different chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Acciones bioquímicas o fisiológicas

La metformina es un antidiabético que reduce las concentraciones de glucosa en sangre y mejora la sensibilidad a la insulina. Sus efectos metabólicos, entre ellos la inhibición de la gluconeogénesis hepática, están mediados al menos en parte por la activación de la ruta LKB1-AMPK (proteína cinasa activada por AMP). La activación de esta vía también parece estar implicada en las acciones antiproliferativas y proapoptóticas de la metformina en las líneas de células cancerosas.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

For chromatography information for this material, please follow the link:https://www.sigmaaldrich.com/US/en/technical-documents/chromatograms/hplc/hplc-dad-analysis-of-metformin-hydrochloride-on-ascentis-express-c18-hplc-column/supelco/app788

Productos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P264 - P270 - P301 + P312 - P501
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3