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I0775020

Isosorbide 2-nitrate

European Pharmacopoeia (EP) Reference Standard

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50 MG
MXP 4,983.00

MXP 4,983.00

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50 MG
MXP 4,983.00

About This Item

Fórmula empírica (notación de Hill):
C6H9NO6
Número de CAS:
16106-20-0
Peso molecular:
191.14
Código UNSPSC:
41116107
NACRES:
NA.24

MXP 4,983.00

Disponible para envío el14 de abril de 2025Detalles

Solicitar un pedido a granel

grado

pharmaceutical primary standard

familia API

isosorbide

fabricante / nombre comercial

EDQM

aplicaciones

pharmaceutical (small molecule)

Formato

neat

cadena SMILES

[N+](=O)([O-])O[C@@H]1[C@H]2OC[C@H]([C@H]2OC1)O

InChI

1S/C6H9NO6/c8-3-1-11-6-4(13-7(9)10)2-12-5(3)6/h3-6,8H,1-2H2/t3-,4+,5-,6-/m1/s1

Clave InChI

YWXYYJSYQOXTPL-JGWLITMVSA-N

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Isosorbide 2-nitrate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

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Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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T B Tzeng et al.
Journal of chromatography, 571(1-2), 109-120 (1991-11-15)
A specific, sensitive and precise capillary gas chromatographic method using electron-capture detection was developed for the determination of four isomeric vasodilating organic mononitrates, viz. L-isoidide mononitrate (L-IIMN), isosorbide-2-mononitrate (IS-2-MN), isomannide mononitrate (IMMN) and isosorbide-5-mononitrate (IS-5-MN), in rat plasma. With a
Riccardo Raddino et al.
Journal of cardiovascular medicine (Hagerstown, Md.), 11(7), 486-492 (2010-04-24)
Nitrates are used in the treatment of coronary heart disease and heart failure. The major drawback of their therapeutic use is the rapid development of tolerance. To investigate the effect of different nitrates on isolated rabbit hearts and aortic strips
Y Gomita et al.
The Journal of pharmacy and pharmacology, 43(11), 811-812 (1991-11-01)
Rats dosed orally with isosorbide dinitrate (1 mg kg-1) were exposed to smoke from standard and nicotine-reduced cigarettes for 8 min using a smoking machine. Plasma concentrations of isosorbide dinitrate and 5-isosorbide mononitrate, one of its major metabolites were approximately
R De Caterina et al.
American heart journal, 119(4), 855-862 (1990-04-01)
Isosorbide monitrates (IS-2-MN and IS-5-MN), hepatic metabolites of isosorbide dinitrate, inhibit platelet function in vitro very differently, with IS-2-MN being much more potent than IS-5-MN. To assess their antiplatelet properties in vivo and to compare time and dosage requirements, we
M G Bogaert
Cardiovascular drugs and therapy, 8(5), 693-699 (1994-10-01)
The pharmacokinetics of organic nitrates are discussed with emphasis on the possible clinical relevance. For glyceryl trinitrate, the measurement of plasma concentrations is very difficult. Its pharmacokinetics are unusual, with a very rapid disappearance from plasma, and large intraindividual and
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