This product is intended for use as an analytical standard and has not been tested for use in other applications. Currently, there is no Doxorubicin HCl product available that has been tested for in vivo or in vitro use. However, the research grade item, D1515, has been used successfully in mice, as cited in several publications. Please see the links below to review articles that may be of interest:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451836/pdf/PAN_2020_v24n2_11.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036477/
D2975000
Doxorrubicina hydrochloride
European Pharmacopoeia (EP) Reference Standard
Sinónimos:
DOX, Hidroxidaunorrubicina hydrochloride
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150 MG
MXP 4,762.00
About This Item
Fórmula empírica (notación de Hill):
C27H29NO11 · HCl
Número de CAS:
Peso molecular:
579.98
Beilstein/REAXYS Number:
4229251
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
Productos recomendados
grade
pharmaceutical primary standard
API family
doxorubicin
manufacturer/tradename
EDQM
mp
216 °C (dec.) (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
SMILES string
Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
InChI
1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
InChI key
MWWSFMDVAYGXBV-RUELKSSGSA-N
Gene Information
human ... TOP2A(7153)
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, has been developed and issued under the Authority of the Issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.
Produced by certain strains of Streptomyces coeruleorubidus or Streptomyces peucetius or obtained by any other means.
For further information and support please go to the website of the issuing Pharmacopoeia.
Produced by certain strains of Streptomyces coeruleorubidus or Streptomyces peucetius or obtained by any other means.
Application
This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia. Their suitability for any other use is not guaranteed and is the sole responsibility of the user. This standard is not intended for human or animal use.
Established for the preparation of the below-given solutions as per European Pharmacopoeia:
Established for the preparation of the below-given solutions as per European Pharmacopoeia:
- Reference solutions (b) and (c) in the testing of related substances in daunorubicin hydrochloride using liquid chromatography (General text 2.2.29), according to the monograph 0662
- Reference solutions (a) and (c) to test related substances in doxorubicin hydrochloride using liquid chromatography (General text 2.2.29), according to the monograph 0714
- Reference solutions (b) and (c) in the testing of related substances in epirubicin hydrochloride using liquid chromatography (General text 2.2.29), according to the monograph 1590
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Certificados de análisis (COA)
Lot/Batch Number
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