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D0950000

Diazoxide

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

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50 MG
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50 MG
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About This Item

Fórmula empírica (notación de Hill):
C8H7ClN2O2S
Número de CAS:
364-98-7
Peso molecular:
230.67
Número MDL:
MFCD00078578
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329798656
NACRES:
NA.24

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grado

pharmaceutical primary standard

familia API

diazoxide

fabricante / nombre comercial

EDQM

aplicaciones

pharmaceutical (small molecule)

Formato

neat

cadena SMILES

CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1

InChI

1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)

Clave InChI

GDLBFKVLRPITMI-UHFFFAOYSA-N

Información sobre el gen

human ... KCNJ11(3767) , KCNJ8(3764)

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Diazoxide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

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Referencia del producto
Descripción
Precios

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H302,H315,H319,H335

Clasificaciones de peligro

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

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Certificados de análisis (COA)

Lot/Batch Number

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Journal of pediatric endocrinology & metabolism : JPEM, 26(3-4), 301-308 (2013-01-19)
Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infants. Its management can be extremely complicated, and may involve medical therapy and surgery. The mainstay of the treatment is to maintain normoglycemia, since hypoglycemia during infancy can
Ved Bhushan Arya et al.
Archives of disease in childhood. Fetal and neonatal edition, 98(4), F356-F358 (2013-01-31)
To characterise the phenotype and genotype of neonates born small-for-gestational age (SGA; birth weight <10th centile) who developed hyperinsulinaemic hypoglycaemia (HH). Clinical information was prospectively collected on 27 SGA neonates with HH, followed by sequencing of KCNJ11 and ABCC8. There
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Mitochondrial depolarization after ATP-sensitive potassium channel activation has been shown to induce cerebral vasodilation by the generation of calcium sparks in smooth muscle. It is unclear, however, whether mitochondrial depolarization in endothelial cells is capable of promoting vasodilation by releasing
Jorge P López-Alonso et al.
Biochemistry, 51(45), 9211-9222 (2012-10-20)
ATP sensitive potassium (K(ATP)) channels are composed of four copies of a pore-forming inward rectifying potassium channel (Kir6.1 or Kir6.2) and four copies of a sulfonylurea receptor (SUR1, SUR2A, or SUR2B) that surround the pore. SUR proteins are members of
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