67667

Kynurenic acid

analytical standard

• Sinónimos: KYNA, 4-Hydroxyquinoline-2-carboxylic acid
• Fórmula empírica (notación de Hill): C₁₀H₇NO₃
• Número de CAS: 492-27-3
• Peso molecular: 189.17
• Beilstein/REAXYS Number: 147451
• EC Number: 207-751-5
• MDL number: MFCD00006753
• UNSPSC Code: 41116107

Propiedades

• grade: analytical standard
• assay: ≥98.0% (HPLC)
• shelf life: limited shelf life, expiry date on the label
• mp: 275 °C (dec.) (lit.)
• application(s): clinical testing
• SMILES string: OC(=O)c1cc(O)c2ccccc2n1
• InChI: 1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
• InChI key: HCZHHEIFKROPDY-UHFFFAOYSA-N

Descripción

General description

Kynurenic acid, a tryptophan metabolite,[1][2] is a naturally occurring NMDA-receptor and an α7 nicotinic acetylcholine receptor antagonist in the human brain with preferential action at both of the glycine (Gly) binding sites of the N-methyl D-aspartate (NMDA)[2] and α7 nicotinic acetylcholine receptors.[3] This implies that the compound can have a physiological interaction with glutaminergic and cholinergic neurotransmission in the brain.[2][3] Kynurenic acid is reported to be found in elevated levels in the cerebrospinal fluid of patients with schizophrenia.[2] Its anticonvulsant and neuroprotective properties are experimentally reported.[4]

Application

Kynurenic acid may be used as an analytical standard for the quantification of the analyte in serum samples,[3][5] food and honeybee products[4] using high-performance liquid chromatography with fluorescence detection.

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Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable