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Merck
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Documentos

59773

Supelco

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol

analytical standard

Sinónimos:

NNAL

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About This Item

Fórmula empírica (notación de Hill):
C10H15N3O2
Número de CAS:
76014-81-8
Peso molecular:
209.25
MDL number:
MFCD00870462
UNSPSC Code:
41116107
PubChem Substance ID:
329758717
NACRES:
NA.24

grade

analytical standard

Quality Level

100

assay

≥92.0% (TLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable
solid phase extraction (SPE): suitable

application(s)

cleaning products
cosmetics
food and beverages
personal care

format

neat

storage temp.

2-8°C

SMILES string

CN(N=O)CCCC(O)C1=CN=CC=C1

InChI

1S/C10H15N3O2/c1-13(12-15)7-3-5-10(14)9-4-2-6-11-8-9/h2,4,6,8,10,14H,3,5,7H2,1H3

InChI key

OGRXKBUCZFFSTL-UHFFFAOYSA-N

General description

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol is one of the major metabolite of nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, which is a carcinogen responsible in inducing lung cancer in smokers.
Standard for Supelco MIP SPE cartridges. For more information request Supelco Literature T407075, T706031

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificados de análisis (COA)

Lot/Batch Number
BCCK6481
BCCG9820
BCCG1059
BCCF4339
BCCD8254

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Supelco

CRM40059

N-Nitrosodimethylamine solution

(−)-Nicotina ≥99% (GC), liquid

Sigma-Aldrich

N3876

(−)-Nicotina

Sung Hoon Jeong et al.
Scientific reports, 11(1), 4536-4536 (2021-02-27)
Children are at risk of exposure to secondhand smoke. We aimed to evaluate the extent of their exposure to it in relation to their parents' smoking status by using biomarkers relevant to smoking. We evaluated 847 school-age children (6-12 years) who
Steven G Carmella et al.
Chemical research in toxicology, 15(4), 545-550 (2002-04-16)
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a tobacco-specific lung carcinogen which may play an important role as a cause of lung cancer in smokers. NNK is extensively metabolized to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), which like NNK is a potent pulmonary carcinogen. NNAL in turn is
Yi Wang et al.
Cancer prevention research (Philadelphia, Pa.), 13(5), 483-492 (2020-02-28)
Tobacco smoking is the primary risk factor for lung cancer, driven by the addictive nature of nicotine and the indisputable carcinogenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) as well as other compounds. The integration of lung cancer chemoprevention with smoking cessation is one
S S Hecht et al.
Carcinogenesis, 18(9), 1851-1854 (1997-11-05)
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is an important metabolite of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Using the chiral derivatizing agent, (R)-(+)-alpha-methylbenzyl isocyanate [(R)-(+)-MBIC], previous work has shown that the enantiomeric ratio of metabolically formed NNAL and its glucuronide derivative may be species dependent.
S S Hecht et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 4(8), 877-884 (1995-12-01)
Epidemiological studies indicate that vegetable consumption protects against lung cancer in humans, but the protective constituents have not been identified. Phenethyl isothiocyanate (PEITC), which is release upon chewing of watercress (nasturtium officinale), is a chemopreventive agent against lung cancer induced
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