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46127

Sigma-Aldrich

7-Ethoxy-4-(trifluoromethyl)coumarin

suitable for fluorescence, ≥98.0% (TLC)

Sinónimos:

Ethyl 4-(trifluoromethyl)umbelliferyl ether

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About This Item

Fórmula empírica (notación de Hill):
C12H9F3O3
Número de CAS:
115453-82-2
Peso molecular:
258.19
Beilstein/REAXYS Number:
8555209
MDL number:
MFCD00467588
UNSPSC Code:
12352204
PubChem Substance ID:
24869840

assay

≥98.0% (TLC)

solubility

DMF: soluble
DMSO: soluble
methanol: soluble

fluorescence

λex 333 nm; λem 415 nm in methanol

suitability

suitable for fluorescence

SMILES string

CCOc1ccc2c(OC(=O)C=C2C(F)(F)F)c1

InChI

1S/C12H9F3O3/c1-2-17-7-3-4-8-9(12(13,14)15)6-11(16)18-10(8)5-7/h3-6H,2H2,1H3

InChI key

OLHOIERZAZMHGK-UHFFFAOYSA-N

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Other Notes

Substrate for monitoring the activity of cytochrome P450

replaced by

Referencia del producto
Descripción
Precios

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
1336926
429539/1
426319/1
386498/1
382955/1

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Emily E Scott et al.
Chemical research in toxicology, 15(11), 1407-1413 (2002-11-20)
Until recently, all known structures of bacterial cytochromes P450 suggested that substrate access to the buried active site occurred via the F-G region, a surface loop distal to the heme cavity. However, the structure of P450 51 indicates a large
Shih-Feng Lan et al.
Toxicology in vitro : an international journal published in association with BIBRA, 24(4), 1314-1323 (2010-02-23)
In this study, we have evaluated the use of ultra-sterile alginate hydrogels encapsulated with HepG2 liver cells for applications in high throughput drug screening. We have studied the cellular viability and metabolic capacity of the encapsulated cells in two different
Chitra Sridar et al.
The Journal of pharmacology and experimental therapeutics, 301(3), 945-952 (2002-05-23)
Tamoxifen is primarily used in the treatment of breast cancer. It has been approved as a chemopreventive agent for individuals at high risk for this disease. Tamoxifen is metabolized to a number of different products by cytochrome P450 enzymes. The
Ute M Kent et al.
Archives of biochemistry and biophysics, 423(2), 277-287 (2004-03-06)
Mechanistic studies with N-benzyl-1-aminobenzotriazole (BBT)-inactivated cytochrome P450 2B1 were conducted to determine which step(s) in the reaction cycle had been compromised. Stopped-flow studies, formation of the oxy-ferro intermediate, and analysis of products suggested that the reductive process was slower with
Rusty W Kelley et al.
Biochemistry, 44(7), 2632-2641 (2005-02-16)
The presence of one P450 can influence the catalytic characteristics of a second enzyme through the formation of heteromeric P450 complexes. Such a complex has been reported for mixed reconstituted systems containing NADPH-cytochrome P450 reductase, CYP2B4, and CYP1A2, where a
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