MABS442
Anti-Myotubularin Antibody, clone 1G6
ascites fluid, clone 1G6, from mouse
Sinónimos:
Myotubularin
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
En este momento no podemos mostrarle ni los precios ni la disponibilidad
Productos recomendados
origen biológico
mouse
Nivel de calidad
forma del anticuerpo
ascites fluid
tipo de anticuerpo
primary antibodies
clon
1G6, monoclonal
reactividad de especies
mouse, yeast, human
técnicas
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotipo
IgG1κ
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... MTM1(4534)
Descripción general
Myotubularin is a cytoplasmic phosphatase which belongs to the protein-tyrosine phosphatase family. It contains a GRAM domain and a myotubularin phosphatase domain. Myotubularin targets phosphoinositide substrates, including phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). It may also dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Myotubularin indirectly regulates many cellular processes that are facilitated by phosphoinositides, and plays an important role in the formation and morphology of membrane-bound intracellular structures such as vacuoles and mitochondria. It also regulates the transport of EGFR from late endosomes to lysosomes, resulting in the degradation of EGFR. Defects in myotubularin result in X-linked myotubular myopathy, a congenital muscle-wasting condition that affects the limb girdle, trunk, and neck muscles. It has also been implicated in other neuromuscular diseases, such as Charcot-Marie-Tooth disease type 4B.
Inmunógeno
Epitope: N-terminus
Ovalbumin-conjugated recombinant protein corresponding to the N-terminus of human Myotubularin.
Aplicación
Research Category
Signaling
Signaling
Research Sub Category
Signaling Neuroscience
Signaling Neuroscience
This Anti-Myotubularin Antibody, clone 1G6 is validated for use in western blotting, ICC & IP for the detection of Myotubularin.
Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected Myotubularin in 10 µg of HL-60 cell lysate.
Western Blotting Analysis: A representative lot from an independent laboratory detected Myotubularin in lymphoblast lysates (Laporte, J., et al. (2002). J Cell Sci. 115(Pt 15):3105-3117.).
Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated Myotubularin from C2C12 cell lysates. (Laporte, J., et al. (2002). J Cell Sci. 115(Pt 15):3105-3117.).
Immunocytochemistry Analysis: A representative lot from an independent laboratory detected Myotubularin from C2C12 cells. (Buj-Bello, A. et al. (2002). Hum Mol Genet. 11(19):2297-2307.).
Western Blotting Analysis: A representative lot from an independent laboratory detected Myotubularin in lymphoblast lysates (Laporte, J., et al. (2002). J Cell Sci. 115(Pt 15):3105-3117.).
Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated Myotubularin from C2C12 cell lysates. (Laporte, J., et al. (2002). J Cell Sci. 115(Pt 15):3105-3117.).
Immunocytochemistry Analysis: A representative lot from an independent laboratory detected Myotubularin from C2C12 cells. (Buj-Bello, A. et al. (2002). Hum Mol Genet. 11(19):2297-2307.).
Calidad
Evaluated by Western Blotting in HeLa cell lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Myotubularin in 10 µg of HeLa cell lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Myotubularin in 10 µg of HeLa cell lysate.
Descripción de destino
~70 kDa observed
Forma física
Mouse monoclonal IgG1κ in ascites without preservatives.
Unpurified
Almacenamiento y estabilidad
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
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