Scribble is a tumor suppressor marker first discovered in Drosophila that has been implicated in the control of cell proliferation, polarity, invasion, and metastasis (Humbert, et al, 2003). Mammalian Scribble expresses basolateral staining in epithelial tissue and highly polarized expression in T lymphocytes (Dow, et al, 2003) (Ludford-Menting, et al, 2005), and plays an essential role in the regulation of the polarity specifically involved in directed epithelial migration. Altered expression of human Scribble is associated with invasive epithelial cancers, however, its role in tumour development remains unclear (Dow, et al, 2007).
Especificidad
Predicted to cross react with mouse based on sequence homology. Reactivity with other species has not been tested.
Inmunógeno
Epitope: PDZ2 domain of Scribble
GST-tagged fusion protein corresponding to the PDZ2 domain of Scribble
Aplicación
Suggested dilutions: Western blot: 0.2 µg (1:2000)
Research Sub Category Tumor Markers
Cytoskeleton
This Anti-Scribble Antibody is validated for use in WB for the detection of Scribble.
Calidad
Routinely evaluated by Western blot on HeLa cell lysates.
Descripción de destino
220 kDa
Forma física
Format: Purified
Purified in PBS containing with 0.05% NaN3.
Almacenamiento y estabilidad
Maintain at 2-8°C for up to 1 year after date of receipt.
Otras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Información legal
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
GenBank is a registered trademark of United States Department of Health and Human Services
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Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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