GF307
β-NGF Protein, Human Recombinant Animal Free
The Nerve Growth Factor is a well characterized neurotropic protein that plays a critical role in the development of sympathetic & some sensory neurons in the peripheral nervous system. Manufactured using all non-animal reagents.
Sinónimos:
Nerve Growth Factor, NGF, BNGF, Beta NGF
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About This Item
Código UNSPSC:
12352202
eCl@ss:
32160405
NACRES:
NA.77
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Nivel de calidad
Ensayo
>98% (SDS-PAGE and HPLC)
impurezas
<0.1 μg/mg protein endotoxin (<1EU/μg)
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
dry ice
Descripción general
Nerve Growth Factor (β-NGF) is a well characterized neurotropic protein that plays a critical role in the development of sympathetic and some sensory neurons in the peripheral nervous system. In addition, NGF can also act in the central nervous system as a trophic factor for basal forebrain cholinergic neurons. NGF has also been shown to have biological effects on nonneuronal tissues. β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of human β-NGF is a noncovalently disulfide-linked homodimer, of two 13.5 kDa polypeptide monomers (238 total amino acid residues). The three disulfide bonds are required for biological activity.
Product Source: E. coli
Especificidad
Cross Reactivty
Chicken, Hamster, Mouse, Rat
Chicken, Hamster, Mouse, Rat
Aplicación
Research Category
Neuroscience
Neuroscience
Research Sub Category
Growth Factors & Receptors
Growth Factors & Receptors
Calidad
Bioactivity assay: Assay 1: Determined by the dose-dependent stimulation of the proliferation of human TF-1 cells. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
Assay 2: Determined by its ability to stimulate chick E9 DRG neurite outgrowth. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
Assay 2: Determined by its ability to stimulate chick E9 DRG neurite outgrowth. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
Forma física
Product is filtered through a 0.2 micron filter before lyophilization.
Recombinant animal free human β-NGF is manufactured using all non-animal reagents
Almacenamiento y estabilidad
Store at -20°C for up to 6 months from date of receipt.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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