FCMAB104A4

Anti-phospho H3 (Ser10) Antibody, clone 3H10 Alexa Fluor^™ 488

clone 3H10, from mouse, ALEXA FLUOR^™ 488

• Sinónimos: H3 histone, family 3A, H3S10P, Histone H3 (phospho S10), H3 histone, family 3A, H3 histone, family 3B, H3 histone, family 3B (H3.3B)
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• Nivel de calidad: 100
• conjugado: ALEXA FLUOR^™ 488
• forma del anticuerpo: purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: 3H10, monoclonal
• reactividad de especies: human
• técnicas: flow cytometry: suitable
• isotipo: IgG1κ
• Nº de acceso NCBI: NM_003493
• Nº de acceso UniProt: Q16695
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: phosphorylation (pSer10)
• Información sobre el gen: human ... HIST1H3F(8968)

Descripción

Descripción general

Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.

Especificidad

Broad species cross-reactivity is expected.

Histone H3 phosphorylated at Ser10

Inmunógeno

A proprietary immunogen based on a peptide sequence containing phospho-serine corresponding to residue 10 of human histone H3.

Epitope: Ser10

Aplicación

Anti-Phospho-Histone H3 (Ser10) Antibody, clone 3H10, Alexa Fluor^™ 488, is a Mouse Monoclonal Antibody for detection of Histone H3 phosphorylated at serine 10. This purified mAb, also known as H3S10p,
is labeled with Alexa Fluor 488 and validated for use in FC.

Research Category
Epigenetics & Nuclear Function

Apoptosis & Cancer

Research Sub Category
Histones

Cell Cycle, DNA Replication & Repair

Calidad

Evaluated by Flow Cytometry with Jurkat cells.

Descripción de destino

17 kDa observed

Forma física

Protein G Purified

Purified mouse IgG1k conjugated to Alexa Fluor^™ 488 in PBS with 15mg/mL BSA and less than 0.09% sodium azide.

Almacenamiento y estabilidad

Maintain refrigerated at 2-8oC in undiluted aliquots for up to 6 months from date of receipt. Protect from light.

Nota de análisis

Control
Jurkat Cells

Información legal

ALEXA FLUOR is a trademark of Life Technologies

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable