Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
Specificity
Antibody recognizes human Histone H3 dimethylated on lysine 9.
Immunogen
Epitope: Methylated at Lys9dimethylated Lys 9 of Human Histone H3
KLH-conjugated, 2X-branched synthetic peptide corresponding to dimethyl-lysine at residue 9 of human Histone H3.
Application
Milli-Mark Anti-dimethyl-Histone H3 (Lys9)-Alexa Fluor488 Antibody detects level of dimethyl-Histone H3 (Lys9)-Alexa Fluor488 & has been published & validated for use in FC.
Research Category Epigenetics & Nuclear Function
Research Sub Category Histones
Quality
Evaluated by flow cytometry using HeLa cells
Target description
15.5 kDa Calculated
Physical form
Protein A purified
Purified rabbit polyclonal IgG conjugated to Alexa Fluor 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA
Storage and Stability
Maintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.
Analysis Note
Control HeLa Cells
Legal Information
ALEXA FLUOR is a trademark of Life Technologies
MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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