ABT404

Anti-CAPN6 Antibody

from rabbit, purified by affinity chromatography

• Sinónimos: Calpain-6, Calpain-like protease X-linked, Calpamodulin, CalpM
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: rat, human
• técnicas: immunofluorescence: suitable; immunohistochemistry: suitable; western blot: suitable
• Nº de acceso UniProt: Q9Y6Q1
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... CAPN6(827)

Descripción

Descripción general

Calpain-6, also known as Calpain-like protease X-linked or Calpamodulin (CalpM) and encoded by the gene name CAPN6 or CALPM, belongs to a well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. This large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes as their activation can be triggered by calcium influx and oxidative stress. CAPN6 is most similar to Calpain 5; the C-terminal region of CAPN6 lacks homology to the calmodulin like domain of other vertebrate calpains. CAPN6 is thought to be involved in the regulation of microtubule dynamics and cytoskeletal organization. CAPN6 has also been recently identified as an HIV dependency factor (HDF), suggesting that CAPN6 may be an important drug target in HIV treatment.

Inmunógeno

Epitope: C-terminus

KLH-conjugated synthetic peptide corresponding to the C-terminus of human CAPN6.

Aplicación

Anti-CAPN6 Antibody is an antibody against CAPN6 for use in western blotting, IHC & immunofluorescence.

Immunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected CAPN6 in human lung tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected CAPN6 in human lung cells.

Research Category
Cell Structure

Research Sub Category
Cytoskeleton

Calidad

Evaluated by Western Blotting in rat lung tissue lysate.

Western Blotting Analysis: 1 μg/mL of this antibody detected CAPN6 in rat lung tissue lysate.

Descripción de destino

~75 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Forma física

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable