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ABN418

Sigma-Aldrich

Anti-TRPM4 Antibody

from rabbit, purified by affinity chromatography

Sinónimos:

Transient receptor potential cation channel subfamily M member 4, hTRPM4, Calcium-activated non-selective cation, channel 1, Long transient receptor potential channel 4, LTrpC-4, LTrpC4, Melastatin-4

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, rat

species reactivity (predicted by homology)

mouse (based on 100% sequence homology), monkey (based on 100% sequence homology), chimpanzee (based on 100% sequence homology)

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_060106

UniProt accession no.

Q8TD43

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... TRPM4(54795)

General description

TRPM4, also known as Calcium-activated non-selective cation channel 1, Long transient receptor potential channel 4, Melastatin-4 or LTrpC4, and encoded by the gene TRPM4/LTRPC4, is a calcium activated non-selective ion channel for Na+, K+, Cs+ and Li+ ions. TRPM4 plays a central role in membrane depolarization in cardiomyocytes, cortical and dorsal root neurons, endocrine cells, kidney epithelial cells and even hair cells. Additionally, TRPM4 participates in T-cell activation, IL-2 production, blood vessel constriction, insulin secretion and even cell proliferation in various cell types through the up regulation of the beta catenin signaling pathway. TRPM4 is localized to the cell membrane and golgi apparatus and endoplasmic reticulum. TRPM4 is widely expressed. Defects in TRPM4 may be associated with progressive familial heart block disorder which can be a fatal though unpredictable syndrome.

Immunogen

BCP-conjugated linear peptide corresponding to human TRPM4 near the N-terminal.

Application

Anti-TRPM4 Antibody detects level of TRPM4 & has been published & validated for use in TRPM4.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TRPM4 in human cerebellum and human prostate tissue.

Quality

Evaluated by Western Blotting in human cerebellum tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected TRPM4 in 10 µg of human cerebellum tissue lysate.

Target description

~150 kDa observed. Uniprot describes 2 isoforms produced by alternative splicing at ~130 kDa and ~147 kDa

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Jing Yan et al.
Cell reports. Medicine, 5(2), 101413-101413 (2024-02-08)
Toxic signaling by extrasynaptic NMDA receptors (eNMDARs) is considered an important promoter of amyotrophic lateral sclerosis (ALS) disease progression. To exploit this therapeutically, we take advantage of TwinF interface (TI) inhibition, a pharmacological principle that, contrary to classical NMDAR pharmacology
Ge Li et al.
mBio, 11(6) (2020-12-10)
Successful treatment of HIV-infected patients with combinational antiretroviral therapies (cART) can now prolong patients' lives to nearly normal life spans. However, the new challenge faced by many of those HIV-infected patients is chronic neuroinflammation and neurotoxicity that often leads to
Jiyoung Lee et al.
Nature communications, 11(1), 4283-4283 (2020-09-05)
Our understanding of the spatiotemporal regulation of cardiogenesis is hindered by the difficulties in modeling this complex organ currently by in vitro models. Here we develop a method to generate heart organoids from mouse embryonic stem cell-derived embryoid bodies. Consecutive

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