Histone N(ϵ)-methyl lysine demethylases are important in epigenetic regulation. JMJD2E (KDM4E) also known as Lysine-specific demethylase 4E, histone lysine demethylase 4E, or KDM4D-like protein, and encoded by the gene KDM4E/KDM4DL, is a member of the large Fe(II)/2-oxoglutarate- dependent family of human histone demethylases. JMJD2E (KDM4E) is a histone demethylase that specifically demethylates ′Lys-9′ of histone H3, thereby playing a central role in histone code. The KDM4 family also includes KDM4A, KDM4B, KDM4C, and KDM4D. These are also referred to as JMDM3A/JMJD2A, JMDM3B/JMJD2B, JMDM3C/JMJD2C, and JMDM3D/JMJD2D, respectively. Steady-state assays showed that KDM4E has a graded response to O2 over a physiologically relevant range of O2 concentrations, with activity level being dependent upon the methylation status of the target protein, and research with JMJD2E(KDM4E) may indicate the potential for histone demethylase activity to be regulated by oxygen availability.
Immunogen
Linear peptide corresponding to JMJD2E/KDM4E.
Application
Detect JMJD2E/KDM4E using this Anti-JMJD2E/KDM4E antibody validated for use in western blotting.
Quality
Evaluated by Western Blotting in PC-12 cell lysate.
Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected JMJD2E/KDM4E in 10 µg of PC-12 cell lysate.
Target description
~65 kDa observed
¿No encuentra el producto adecuado?
Pruebe nuestro Herramienta de selección de productos.
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Hypoxia is a physiological stress that frequently occurs in solid tissues. Autophagy, a ubiquitous degradation/recycling system in eukaryotic cells, renders cells tolerant to multiple stressors. However, the mechanisms underlying autophagy initiation upon hypoxia remains unclear. Here we show that protein
Questions
Reviews
★★★★★ No rating value
Active Filters
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
