676490

VEGFR2_D1-7, Human, Recombinant, S. frugiperda

• Sinónimos: Vascular Endothelial Growth Factor Receptor 2 _D1-7, Soluble KDR/Flk-1
• Código UNSPSC: 12352202
• NACRES: NA.77

Propiedades

• Ensayo: ≥90% (SDS-PAGE)
• Nivel de calidad: 100
• Formulario: lyophilized
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• solubilidad: aqueous buffer: ≥100 μg/mL; water: ≥100 μg/mL
• Condiciones de envío: wet ice
• temp. de almacenamiento: −70°C

Descripción

Descripción general

Recombinant, human VEGFR-2 consisting of all 7 immunoglobulin-like extracellular domains, but lacking the single transmembrane region and the intracellular split tyrosine kinase domain expressed in S. frugiperda insect cells. Contains all of the domains necessary for high affinity binding to VEGF. VEGFR-2 has a lower affinity for VEGF165 than VEGFR-1. However, VEGFR-2 has a higher signaling activity and is reported to mediate almost all observed endothelial cell responses to VEGF, including the increased microvascular permeability and endothelial cell proliferation. VEGFR-2 requires heparin for binding VEGF165.

Acciones bioquímicas o fisiológicas

Measured by the ability to inhibit VEGF165-induced proliferation in human umbilical vein endothelial (HUVE) cells

Advertencia

Toxicity: Standard Handling (A)

Forma física

Lyophilized from 100 mM NaCl, 25 mM MES, pH 5.5.

Reconstitución

Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C. Avoid freeze/thaw cycles of solutions.

Otras notas

Robinson, C.J., and Stringer, S.E. 2001 J. Cell Sci.114, 853.
Roeckl, W., et al. 1998. Exp. Cell Res.241, 161.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable